| Effect of aminooxyacetic acid on extracellular level of D-serine in rat striatum: an in vivo microdialysis study. | |
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MedLine Citation:
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PMID: 16289454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To elucidate the effect of an inhibitor of pyridoxal phosphate-dependent enzymes, aminooxyacetic acid, on the activity of serine racemase in vivo, we have investigated the effect of aminooxyacetic acid on the extracellular concentration of D-serine in the rat striatum using an in vivo microdialysis technique. The intrastriatal perfusion of aminooxyacetic acid caused a significant decline in the extracellular concentration of D-serine. These data, together with the fact that serine racemase is a pyridoxal phosphate-dependent enzyme, suggest that the aminooxyacetic acid-induced reduction of the extracellular D-serine may be at least in part due to the drug's ability to inhibit serine racemase. |
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Authors:
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Atsushi Hashimoto; Masanobu Yoshikawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-11-14 |
Journal Detail:
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Title: European journal of pharmacology Volume: 525 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-28 Completed Date: 2006-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 91-3 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, 259-1143, Japan. hashimot@is.icc.u-tokai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aminooxyacetic Acid
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pharmacology* Animals Corpus Striatum / drug effects*, metabolism Enzyme Inhibitors / pharmacology* Extracellular Space / metabolism Male Microdialysis Racemases and Epimerases / antagonists & inhibitors Rats Rats, Wistar Serine / analogs & derivatives*, metabolism* Sodium Channel Blockers / pharmacology Tetrodotoxin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Sodium Channel Blockers; 4368-28-9/Tetrodotoxin; 56-45-1/Serine; 645-88-5/Aminooxyacetic Acid; EC 5.1.-/Racemases and Epimerases; EC 5.1.1.16/serine racemase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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