Document Detail

Effect of amino acids on insulin-stimulated glucose metabolism in fat cells.
MedLine Citation:
PMID:  7016847     Owner:  NLM     Status:  MEDLINE    
The effect of amino acids on insulin responsiveness in epididymal adipose tissue was examined. It was found that insulin-stimulated glucose oxidation in fat cells was significantly inhibited by glycine, alanine, valine, leucine, isoleucine, cysteine, methionine, lysine, phenylalanine, and proline. The effect of insulin on glucose incorporation into triglyceride is also severely diminished by these amino acids. In addition, alanine reduced the incorporation of precursors ([U-14C]glucose or [1-14C]palmitate) into triglyceride both in vitro and in vivo. The Ki values of alanine were 0.4 and 0.5 mM toward the precursors of glucose and palmitate, respectively. The mechanism of reduction of insulin responsiveness in rat adipose tissue is discussed on the basis of these results.
T Mizunuma; Y Takahashi; H Okuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biochemistry     Volume:  89     ISSN:  0021-924X     ISO Abbreviation:  J. Biochem.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2007-12-19    
Medline Journal Info:
Nlm Unique ID:  0376600     Medline TA:  J Biochem     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  407-10     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / metabolism*
Amino Acids / pharmacology*
Glucose / metabolism*
Insulin / pharmacology*
Time Factors
Triglycerides / biosynthesis
Reg. No./Substance:
0/Amino Acids; 0/Triglycerides; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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