Document Detail

Effect of amino acids on the expression of antiviral activity of different types of human interferon. I. Effect of single amino acids.
MedLine Citation:
PMID:  3012929     Owner:  NLM     Status:  MEDLINE    
It has been observed that certain amino acids may influence the antiviral activity of different types of human interferon (IFN). The effect may be enhancing or inhibitory. A qualitative survey is provided on all three types of human IFN using 23 different amino acids. A more detailed study was carried out with 10 amino acids which proved to be active towards HuIFN-alpha. Their influences on the synergistic antiviral effects of HuIFN-alpha and HuIFN-gamma were also investigated. The dose-dependence curves of their effects on HuIFN-alpha were established.
S Tóth; I Mécs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta microbiologica Hungarica     Volume:  32     ISSN:  0231-4622     ISO Abbreviation:  Acta Microbiol. Hung.     Publication Date:  1985  
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8400270     Medline TA:  Acta Microbiol Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  363-8     Citation Subset:  IM    
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MeSH Terms
Amino Acids / pharmacology*
Cell Line
Drug Synergism
Interferon Type I / pharmacology*
Interferon-gamma / pharmacology*
Structure-Activity Relationship
Vesicular stomatitis Indiana virus / drug effects*
Reg. No./Substance:
0/Amino Acids; 0/Interferon Type I; 82115-62-6/Interferon-gamma

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