Document Detail


Effect of amino acids on cell proliferation and protein p53 expression in organotypic culture of lymphoid tissue from neonatal rats.
MedLine Citation:
PMID:  18948218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of the larger molecular weight l-amino acids on the development of spleen explants from 1- and 21-day rats in organotypic tissue culture was studied. The amino acids asparagine, lysine, arginine, and glutamic acid inhibited the growth zone of explants of immature tissue from 1-day animals but had an opposite, stimulating, effect on mature spleen tissue of 21-day rats. Immunohistochemical analysis revealed a reciprocal correlation between the expression of the proapoptotic protein, p53, and T-cell proliferation in response to lysine, asparagine, and glutamic acid. Interestingly only arginine reduced the area of p53 expression both in explants of mature and immature spleen tissue. The ability of arginine to reduce p53 expression can be suggested as one of the mechanisms of the tumor growth stimulation.
Authors:
N I Chalisova; A N Zakutskii
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Publication Detail:
Type:  Journal Article     Date:  2008-10-07
Journal Detail:
Title:  Cell biology international     Volume:  32     ISSN:  1095-8355     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-18     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1574-7     Citation Subset:  IM    
Affiliation:
Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg 199034, Russia. ni_chalisova@mail.ru
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Amino Acids / metabolism,  pharmacology*
Animals
Animals, Newborn
Arginine / metabolism,  pharmacology
Asparagine / metabolism,  pharmacology
Cell Differentiation / drug effects,  physiology
Cell Proliferation / drug effects*
Down-Regulation / drug effects,  immunology
Glutamic Acid / metabolism,  pharmacology
Lymphocyte Activation / drug effects
Lymphoid Tissue / drug effects*,  growth & development,  metabolism
Lysine / metabolism,  pharmacology
Organ Culture Techniques
Rats
Rats, Wistar
Spleen / drug effects,  growth & development,  metabolism
T-Lymphocytes / drug effects*,  metabolism
Tumor Suppressor Protein p53 / drug effects*,  immunology,  metabolism
Up-Regulation / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Tumor Suppressor Protein p53; 56-86-0/Glutamic Acid; 56-87-1/Lysine; 7006-34-0/Asparagine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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