Document Detail

Effect of amino acids on cell proliferation and protein p53 expression in organotypic culture of lymphoid tissue from neonatal rats.
MedLine Citation:
PMID:  18948218     Owner:  NLM     Status:  MEDLINE    
The effect of the larger molecular weight l-amino acids on the development of spleen explants from 1- and 21-day rats in organotypic tissue culture was studied. The amino acids asparagine, lysine, arginine, and glutamic acid inhibited the growth zone of explants of immature tissue from 1-day animals but had an opposite, stimulating, effect on mature spleen tissue of 21-day rats. Immunohistochemical analysis revealed a reciprocal correlation between the expression of the proapoptotic protein, p53, and T-cell proliferation in response to lysine, asparagine, and glutamic acid. Interestingly only arginine reduced the area of p53 expression both in explants of mature and immature spleen tissue. The ability of arginine to reduce p53 expression can be suggested as one of the mechanisms of the tumor growth stimulation.
N I Chalisova; A N Zakutskii
Related Documents :
2453168 - Amino-acid-enzyme activities in brown and white adipose tissues and in the liver of caf...
12091108 - Comparison of lipids in selected tissues of the florida manatee (order sirenia) and bot...
2905978 - Clenbuterol stimulated increase of plasma free fatty acids in reserpinized pigs.
4053568 - Fatty acid synthesis from amino acids in sheep adipose tissue.
18810998 - Evaluation of lipoxygenase inhibitory activity of anacardic acids.
18476868 - Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and adva...
Publication Detail:
Type:  Journal Article     Date:  2008-10-07
Journal Detail:
Title:  Cell biology international     Volume:  32     ISSN:  1095-8355     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-18     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1574-7     Citation Subset:  IM    
Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg 199034, Russia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / metabolism
Amino Acids / metabolism,  pharmacology*
Animals, Newborn
Arginine / metabolism,  pharmacology
Asparagine / metabolism,  pharmacology
Cell Differentiation / drug effects,  physiology
Cell Proliferation / drug effects*
Down-Regulation / drug effects,  immunology
Glutamic Acid / metabolism,  pharmacology
Lymphocyte Activation / drug effects
Lymphoid Tissue / drug effects*,  growth & development,  metabolism
Lysine / metabolism,  pharmacology
Organ Culture Techniques
Rats, Wistar
Spleen / drug effects,  growth & development,  metabolism
T-Lymphocytes / drug effects*,  metabolism
Tumor Suppressor Protein p53 / drug effects*,  immunology,  metabolism
Up-Regulation / drug effects,  physiology
Reg. No./Substance:
0/Amino Acids; 0/Tumor Suppressor Protein p53; 56-86-0/Glutamic Acid; 56-87-1/Lysine; 7006-34-0/Asparagine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Association with actin mediates the EGTA-resistant binding of cytosolic phospholipase A2-alpha to th...
Next Document:  ATF-1 transcription factor regulates the expression of ccg-1 and cat-1 genes in response to fludioxo...