| Effect of amino acid mixture on the isolated ischemic heart. | |
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MedLine Citation:
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PMID: 15094103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Data show that uptake of amino acids correlates with myocardial oxygen consumption after aortic cross-clamp in humans; this suggests a direct link between amino acids and myocardial energy metabolism. The aim of this preliminary study was to investigate the anti-ischemic effects of immediate and long-term supplementation of an amino acid mixture. We tested this hypothesis on isolated rats hearts subjected to global ischemia for 30 minutes. Long-term treatment with an amino acid mixture achieved the following: (1) reduced the increase of diastolic pressure (48 +/- 3 mm Hg vs 21 +/- 4 mm Hg; p <0.05); (2) maintained the tissue content of adenosine triphosphate during ischemia (2.5 +/- 0.6 micromol/g wet wt [gww] vs 7.0 +/- 1.2 micromol/gww; p <0.05); and (3) improved the recovery of developed pressure at the end of postischemic reperfusion (11 +/- 2 mm Hg vs 38 +/- 3 mm Hg; p <0.05), reducing the release of creatine kinase (375 +/- 30 microU/min/gww vs 196 +/- 15 microU/min/gww; p <0.05) and lactate (15 +/- 1.5 mg/min/gww vs 5 +/- 1 mg/min/gww; p <0.05). We conclude that long-term supplementation of an amino acid mixture reduced myocardial ischemic damage. |
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Authors:
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Evasio Pasini; Tiziano M Scarabelli; Giuseppe D'Antona; Francesco S Dioguardi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 93 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-19 Completed Date: 2004-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 30A-34A Citation Subset: AIM; IM |
Affiliation:
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Service of Metabolic and Nutritional Pathophysiology, Salvatore Maugeri Foundation, IRCCS, Medical Center of Montescano, Pavia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Administration, Oral Amino Acids, Essential / administration & dosage* Animals Creatine Kinase / metabolism Dietary Proteins / administration & dosage* Dietary Supplements* Disease Models, Animal Lactic Acid / metabolism Male Myocardial Ischemia / diet therapy* Myocardium / metabolism Phosphocreatine / metabolism Rats Rats, Sprague-Dawley Ventricular Function, Left / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Essential; 0/Dietary Proteins; 50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; EC 2.7.3.2/Creatine Kinase |
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