| Effect of ambient temperatures ranging from cold to heat on thermoregulation in conscious MK801-treated rats. | |
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MedLine Citation:
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PMID: 14608413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The glutamate NMDA receptor has been suggested to be involved in thermoregulation. To further analyse its role, the thermoregulatory responses of rats treated with 0.5 mg.kg-1 of dizocilpine (MK801) were compared with those of control rats treated only with the same volume of saline during a 180-min exposure at one of the six different ambient temperatures, ranging from cold to heat. Colonic temperature (Tco) and tail skin temperature (Ttail) were measured throughout using Cu-Ct thermocouples. In the cold (2.4 and 12.3 degrees C), Tco decreased either sharply (MK801) or progressively (saline), reaching the same final value (2.4 degrees C) or a lower value in the MK801-treated rats (12.3 degrees C). At the same time, Ttail decreased in both groups. In the cool environment (20.7 degrees C), Tco and Ttail decreased in both groups, with lower final values in MK801-treated rats. At thermoneutrality (28.8 degrees C), the MK801-induced hyperthermia remained steady, while Ttail increased in both groups. In the heat (34.6 and 36.2 degrees C), Tco and Ttail increased in both groups, with higher final values in MK801-treated rats. Moreover, at 36.2 degrees C, only MK801-treated rats exhibited heatstroke. It is thus suggested that MK801-induced inhibition of NMDA receptors impairs thermoregulation, especially in the heat. |
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Authors:
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F Canini; L Bourdon; J Bittel |
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Publication Detail:
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Type: Historical Article; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 81 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-11-10 Completed Date: 2004-07-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: Canada |
Other Details:
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Languages: eng Pagination: 959-65 Citation Subset: IM |
Affiliation:
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Centre de rechercres du Service de santé des armées, Département des facteurs humains, La Tronche, France. fredericcanini@crssa.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / physiology* Cold Temperature* Dizocilpine Maleate / pharmacology* History, Ancient Hot Temperature* Male Motor Activity / drug effects Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, N-Methyl-D-Aspartate; 77086-22-7/Dizocilpine Maleate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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