| Effect of ambient temperature on cardiovascular parameters in rats and mice: a comparative approach. | |
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MedLine Citation:
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PMID: 15087284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ambient air temperatures (T(a)) of <6 degrees C or >29 degrees C have been shown to induce large changes in arterial blood pressure and heart rate in homeotherms. The present study was designed to investigate whether small incremental changes in T(a), such as those found in typical laboratory settings, would have an impact on blood pressure and other cardiovascular parameters in mice and rats. We predicted that small decreases in T(a) would impact the cardiovascular parameters of mice more than rats due to the increased thermogenic demands resulting from a greater surface area-to-volume ratio in mice relative to rats. Cardiovascular parameters were measured with radiotelemetry in mice and rats that were housed in temperature-controlled environments. The animals were exposed to different T(a) every 72 h, beginning at 30 degrees C and incrementally decreasing by 4 degrees C at each time interval to 18 degrees C and then incrementally increasing back up to 30 degrees C. As T(a) decreased, mean blood pressure, heart rate, and pulse pressure increased significantly for both mice (1.6 mmHg/ degrees C, 14.4 beats.min(-1). degrees C(-1), and 0.8 mmHg/ degrees C, respectively) and rats (1.2 mmHg/ degrees C, 8.1 beats.min(-1). degrees C(-1), and 0.8 mmHg/ degrees C, respectively). Thus small changes in T(a) significantly impact the cardiovascular parameters of both rats and mice, with mice demonstrating a greater sensitivity to these T(a) changes. |
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Authors:
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Steven J Swoap; J Michael Overton; Graham Garber |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Date: 2004-04-15 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 287 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-23 Completed Date: 2004-08-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R391-6 Citation Subset: IM |
Affiliation:
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Department of Biology, Williams College, Williamstown, MA 01267, USA. sswoap@williams.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology* Consciousness Female Heart Rate / physiology* Mice Motor Activity Rats Rats, Sprague-Dawley Species Specificity Telemetry Temperature* |
| Grant Support | |
ID/Acronym/Agency:
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HL-56732/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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