| Effect of aluminium metal on glutathione (GSH) level in plasma and cytosolic fraction of human blood. | |
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MedLine Citation:
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PMID: 21190912 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aluminium is being used in the medicines in the form of antacids. The Aluminium metal can be leached from our utensils and can harm the body for its side effects, if become available to the systemic circulation. So it is important to check the effect of Aluminum on the Glutathione in vivo condition. Ellman method was used to determine the effect of Aluminum on GSH level in whole blood spectrophotometerically. 5,5-Dithiobis, 2-Nitrobenzoic Acid, Glutathione, Aluminium sulphate, phosphate buffer, HCl (Hydrochloric acid) and other laboratory instruments were used to conduct the research work. Time dependent effect of Aluminum on Glutathione level in whole blood was also checked and decrease was observed. This study also shows the effect of Aluminum as helping agent for the Glutathione to enhance the antioxidant system of the body or a cause for depletion of reduced Glutathione. |
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Authors:
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Haroon Khan; M Farid Khan; Syed Umer Jan; Naseem Ullah |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 24 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 13-8 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gomal University, D.I. Khan,Pakistan. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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