Document Detail

Effect of altering cerebrospinal fluid pressure on spinal cord blood flow.
MedLine Citation:
PMID:  8037507     Owner:  NLM     Status:  MEDLINE    
Removal of cerebrospinal fluid (CSF) has been proposed as a means of protecting the spinal cord against ischemic injury during thoracoabdominal aneurysm operations. We investigated the effect of altering CSF pressure (CSFP) on lumbar spinal cord blood flow (SCBF) in an experiment using dogs. The SCBF was measured before and after withdrawal of CSF in settings with and without thoracic aortic clamping. Furthermore, SCBF was measured at the basal state and after elevation of CSFP to 20 mm Hg and to 40 mm Hg. The SCBF did not change significantly before and after removal of CSF in settings both with and without thoracic aortic clamping. Elevation of CSFP significantly reduced SCBF. Elevation of CSFP reduces SCBF, but lowering CSFP per se does not increase SCBF whether the thoracic aorta is occluded or not. This supports the notion that removal of CSF offers spinal cord protection only when CSFP is abnormally elevated.
S Kazama; Y Masaki; S Maruyama; A Ishihara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  58     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-08-18     Completed Date:  1994-08-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  112-5     Citation Subset:  AIM; IM    
Department of Thoracic Surgery, Kitasato University School of Medicine, Kanagawa, Japan.
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MeSH Terms
Aorta, Thoracic
Cerebrospinal Fluid Pressure / physiology*
Ischemia / prevention & control
Paraplegia / prevention & control
Postoperative Complications / prevention & control
Regional Blood Flow / physiology
Spinal Cord / blood supply*

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