Document Detail

Effect of alpha-methyldopa on cardiac output in hypertension.
MedLine Citation:
PMID:  761439     Owner:  NLM     Status:  MEDLINE    
Hemodynamic and blood volume changes, systolic time intervals, and baroreflex mechanisms were studied in 20 patients with hypertension after methyldopa (12 +/- 0.9 mg/kg/day). The drug was administered orally during 7 days' hospitalization on a normal sodium diet (110 mEq/day). There was a fall in blood pressure and in total peripheral resistance, without significant change in cardiac index, heart rate, and stroke index. There were increases in plasma and blood volume (p less than 0.05) but no change in cardiopulmonary blood volume or systolic time intervals. The unchanged heart rate was associated with an increased sensitivity ( less than 0.05) of the baroreflex mechanisms. The study supports the view that the unchanged cardiac output after methyldopa is related to important changes in control of cardiac output, including redistribution of blood volume and modifications in baroreflex mechanisms.
M E Safar; G M London; J A Levenson; M A Kheder; N E Aboras; A C Simon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  25     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-04-28     Completed Date:  1979-04-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  266-72     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Volume / drug effects
Cardiac Output / drug effects*
Heart Rate / drug effects
Hypertension / drug therapy,  physiopathology*
Methyldopa / pharmacology*,  therapeutic use
Middle Aged
Pressoreceptors / drug effects
Reflex / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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