Document Detail

Effect of an alpha-linolenic acid-rich diet on rat mammary tumor growth depends on the dietary oxidative status.
MedLine Citation:
PMID:  10798214     Owner:  NLM     Status:  MEDLINE    
To investigate whether the oxidative status of an 18:3(n-3) polyunsaturated fatty acid (PUFA)-enriched diet could modulate the growth of chemically induced rat mammary tumors, three independent experiments were performed. Experiments I and II examined the variation of tumor growth by addition of antioxidant (vitamin E) or a prooxidant system (sodium ascorbate/2-methyl-1,4-naphthoquinone) to a 15% linseed oil diet rich in 18:3(n-3). Experiment III addressed the role of PUFA in the tumor growth modulation by vitamin E. For this purpose, we compared the effect of vitamin E in 15% fat diets containing a high level of 18:3(n-3) (linseed oil, high-PUFA diet) or devoid of 18:3(n-3) (hydrogenated palm/sunflower oil, low-PUFA diet). In Experiments I-III, tumor growth increased in the presence of vitamin E compared with control (without vitamin E). Furthermore, it decreased when prooxidant was added. In contrast, no difference was observed when the diet was low in PUFA, suggesting that sensitivity of PUFA to peroxidation may interfere with tumor growth. This observation was supported by growth kinetic parameter analysis, which indicated that tumor growth resulted from variations in cell loss but not from changes in cell proliferation. These data show that, in vivo, PUFA effects on tumor growth are highly dependent on diet oxidative status.
S Cognault; M L Jourdan; E Germain; R Pitavy; E Morel; G Durand; P Bougnoux; C Lhuillery
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition and cancer     Volume:  36     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  2000  
Date Detail:
Created Date:  2000-07-19     Completed Date:  2000-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-41     Citation Subset:  IM    
Laboratoire de Nutrition et Sécurité Alimentaire, Institut National de la Recherche Agronomique, Jouy-en-Josas, France.
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MeSH Terms
Antioxidants / administration & dosage
Ascorbic Acid / administration & dosage
Dietary Fats, Unsaturated / administration & dosage*
Linseed Oil
Mammary Neoplasms, Experimental / chemically induced,  pathology*
Naphthoquinones / administration & dosage
Oxidants / administration & dosage*
Rats, Sprague-Dawley
Vitamin E / administration & dosage
Vitamin K 3
alpha-Linolenic Acid / administration & dosage*
Reg. No./Substance:
0/Antioxidants; 0/Dietary Fats, Unsaturated; 0/Naphthoquinones; 0/Oxidants; 1406-18-4/Vitamin E; 463-40-1/alpha-Linolenic Acid; 50-81-7/Ascorbic Acid; 58-27-5/Vitamin K 3; 684-93-5/Methylnitrosourea; 8001-26-1/Linseed Oil

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