Document Detail

Effect of alpha-helical-CRF[9-41] on feeding in goldfish: involvement of cortisol and catecholamines.
MedLine Citation:
PMID:  9106678     Owner:  NLM     Status:  MEDLINE    
The anoretic effect of corticotropin-releasing factor (CRF) was not dependent on adrenal activation in goldfish (Carassius auratus). Moreover, an interaction between CRF and the hypothalamic catecholaminergic system in the central regulation of food intake was observed. The intracerebroventricular (icv) administration of CRF increased cortisol levels and reduced food intake and hypothalamic norepinephrine and dopamine content at 2 hr postinjection, with these effects reversed by alpha-helical CRF[9-41] pretreatment. The anoretic effect of CRF was independent of the circulating cortisol increase, because it was only evoked after icv injections but not after intraperitoneal (ip) administration. Furthermore, the increase in plasma cortisol levels induced by ip administration of this steroid did not modify feeding.
N de Pedro; A L Alonso-Gómez; B Gancedo; A I Valenciano; M J Delgado; M Alonso-Bedate
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  111     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-30     Completed Date:  1997-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  398-403     Citation Subset:  IM    
Departamento de Biología Animal II (Fisiología Animal), Facultad de Ciencias Biológicas, Universidad Complutense, Madrid, Spain.
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MeSH Terms
Appetite / drug effects*,  physiology
Brain / drug effects
Catecholamines / physiology*
Corticotropin-Releasing Hormone / pharmacology*,  physiology
Feeding Behavior / drug effects*,  physiology
Goldfish / physiology*
Hunger / drug effects,  physiology
Hydrocortisone / physiology*
Injections, Intraventricular
Peptide Fragments / pharmacology*
Reg. No./Substance:
0/Catecholamines; 0/Peptide Fragments; 50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone; 96118-75-1/corticotropin releasing hormone (9-41)

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