| Effect of alpha-helical-CRF[9-41] on feeding in goldfish: involvement of cortisol and catecholamines. | |
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MedLine Citation:
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PMID: 9106678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The anoretic effect of corticotropin-releasing factor (CRF) was not dependent on adrenal activation in goldfish (Carassius auratus). Moreover, an interaction between CRF and the hypothalamic catecholaminergic system in the central regulation of food intake was observed. The intracerebroventricular (icv) administration of CRF increased cortisol levels and reduced food intake and hypothalamic norepinephrine and dopamine content at 2 hr postinjection, with these effects reversed by alpha-helical CRF[9-41] pretreatment. The anoretic effect of CRF was independent of the circulating cortisol increase, because it was only evoked after icv injections but not after intraperitoneal (ip) administration. Furthermore, the increase in plasma cortisol levels induced by ip administration of this steroid did not modify feeding. |
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Authors:
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N de Pedro; A L Alonso-Gómez; B Gancedo; A I Valenciano; M J Delgado; M Alonso-Bedate |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behavioral neuroscience Volume: 111 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-06-30 Completed Date: 1997-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 398-403 Citation Subset: IM |
Affiliation:
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Departamento de Biología Animal II (Fisiología Animal), Facultad de Ciencias Biológicas, Universidad Complutense, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite / drug effects*, physiology Brain / drug effects Catecholamines / physiology* Corticotropin-Releasing Hormone / pharmacology*, physiology Feeding Behavior / drug effects*, physiology Goldfish / physiology* Hunger / drug effects, physiology Hydrocortisone / physiology* Injections, Intraventricular Peptide Fragments / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Peptide Fragments; 50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone; 96118-75-1/corticotropin releasing hormone (9-41) |
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