Document Detail


Effect of allopurinol supplementation on nitric oxide levels in asphyxiated newborns.
MedLine Citation:
PMID:  17162192     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study aimed to investigate the effect of allopurinol in the management of cerebral hypoxia-ischemia by monitoring nitric oxide levels of serum and cerebrospinal fluid. Sixty asphyxiated infants were divided randomly into two groups. Group I infants (n = 30) received allopurinol (40 mg/kg/day, 3 days) within 2 hours after birth. Group II infants (n = 30) received a placebo. Twenty healthy neonates served as control subjects. Cerebrospinal fluid and serum nitric oxide levels were measured within 0-24 hours and 72-96 hours after birth. Both serum and cerebrospinal fluid concentrations of nitric oxide were higher in severely asphyxiated infants (40.86 +/- 8.97, 17.3 +/- 3.63 micromol/L, respectively) but lower in mildly asphyxiated infants (25.85 +/- 3.57, 5.70 +/- 2.56 micromol/L, respectively) than in moderately asphyxiated infants (35.86 +/- 5.38, 11.06 +/- 3.37 micromol/L, respectively) within the first 0-24 hours after birth. Serum nitric oxide levels in control subjects were lower than those of moderately and severely asphyxiated infants. Serum nitric oxide levels of Group I infants within 72-96 hours after birth decreased significantly from their corresponding levels within 0-24 hours after birth. The asphyxiated newborns treated with allopurinol had better neurologic and neurodevelopmental outcome at 12 or more months of age.
Authors:
Tamer Gunes; Mehmet Adnan Ozturk; Esad Koklu; Kader Kose; Isin Gunes
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric neurology     Volume:  36     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-24     Citation Subset:  IM    
Affiliation:
Erciyes University, School of Medicine, Department of Pediatrics, Division of Neonatology, Department of Biochemistry, Kayseri, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Allopurinol / administration & dosage*
Asphyxia Neonatorum / complications,  drug therapy*,  metabolism
Child Development
Female
Free Radical Scavengers / administration & dosage*
Humans
Hypoxia, Brain / drug therapy*,  etiology,  metabolism
Infant
Infant, Newborn
Male
Nitric Oxide / blood*,  cerebrospinal fluid
Placebos
Treatment Outcome
Chemical
Reg. No./Substance:
0/Free Radical Scavengers; 0/Placebos; 10102-43-9/Nitric Oxide; 315-30-0/Allopurinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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