Document Detail


Effect of allopurinol, folinic acid, SOD and cyclosporine A on ischemic liver regeneration.
MedLine Citation:
PMID:  7781646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liver regeneration plays a key role in restoring the liver/body ratio after partial liver transplantation. However, hepatic ischemia hinders the proliferative response of the hepatocytes. In this study, different ways of improving the regenerating capacity of ischemic hepatocytes are tested. Following 70% hepatectomy and 15 min of normothermic liver ischemia, the percentage of regenerating hepatocytes and the regenerative gradient are assessed. Cyclosporine A (hepatotrophic agent), superoxide dismutase and folinic acid (antioxidants), administered during the ischemic period, have significantly increased these indices. The later drug has restored the regenerative response to the levels of normoperfused livers.
Authors:
V Portugal; I García-Alonso; P Barceló; J Méndez
Related Documents :
15257246 - Hepatocyte transplantation: state of the art and strategies for overcoming existing hur...
10824976 - Generation of genetically modified mice by spermatozoa transfection in vivo: preliminar...
22416256 - Early il-10 production is essential for syngeneic graft acceptance.
18606676 - Critical role of effector macrophages in mediating cd4-dependent alloimmune injury of t...
2016806 - Calcium metabolism in acidotic patients induced by carbonic anhydrase inhibitors: respo...
22965176 - The impact of chronic obstructive pulmonary disease and smoking on mortality and kidney...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  27     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1995  
Date Detail:
Created Date:  1995-07-14     Completed Date:  1995-07-14     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of The Basque Country, Leioa, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Allopurinol / pharmacology*
Animals
Cyclosporine / pharmacology*
Ischemia / physiopathology*
Leucovorin / pharmacology*
Liver / blood supply*
Liver Regeneration / drug effects*
Male
Rats
Rats, Sprague-Dawley
Superoxide Dismutase / pharmacology*
Chemical
Reg. No./Substance:
315-30-0/Allopurinol; 58-05-9/Leucovorin; 59865-13-3/Cyclosporine; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Improved survival rate after portacaval shunt in the rat using a modified microsurgical technique.
Next Document:  Deterioration of platelet energy metabolism following energy crisis of liver after hepatectomy.