Document Detail

Effect of allopurinol, folinic acid, SOD and cyclosporine A on ischemic liver regeneration.
MedLine Citation:
PMID:  7781646     Owner:  NLM     Status:  MEDLINE    
Liver regeneration plays a key role in restoring the liver/body ratio after partial liver transplantation. However, hepatic ischemia hinders the proliferative response of the hepatocytes. In this study, different ways of improving the regenerating capacity of ischemic hepatocytes are tested. Following 70% hepatectomy and 15 min of normothermic liver ischemia, the percentage of regenerating hepatocytes and the regenerative gradient are assessed. Cyclosporine A (hepatotrophic agent), superoxide dismutase and folinic acid (antioxidants), administered during the ischemic period, have significantly increased these indices. The later drug has restored the regenerative response to the levels of normoperfused livers.
V Portugal; I García-Alonso; P Barceló; J Méndez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  27     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1995  
Date Detail:
Created Date:  1995-07-14     Completed Date:  1995-07-14     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  IM    
Department of Surgery, University of The Basque Country, Leioa, Spain.
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MeSH Terms
Allopurinol / pharmacology*
Cyclosporine / pharmacology*
Ischemia / physiopathology*
Leucovorin / pharmacology*
Liver / blood supply*
Liver Regeneration / drug effects*
Rats, Sprague-Dawley
Superoxide Dismutase / pharmacology*
Reg. No./Substance:
315-30-0/Allopurinol; 58-05-9/Leucovorin; 59865-13-3/Cyclosporine; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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