Document Detail

Effect of allopurinol on adrenergically induced changes in serum lipid levels, heart rate and blood pressure in normal and ischemic rabbits (author's transl)
MedLine Citation:
PMID:  7200779     Owner:  NLM     Status:  MEDLINE    
In accordance with previous results obtained in healthy volunteers 1H-pyrazolo[3,4-d]pyrimidin-4-ol (allopurinol) showed an inhibiting effect on the adrenergically induced mobilization of free fatty acids in normal rabbits. The effect of allopurinol was nearly equal to that of prostaglandin E1 but less than that of pyridyl carbinol. Similarly like in patients with coronary heart disease, this effect was not found in rabbits with cardiac damage following isoprenaline pretreatment. Allopurinol at higher dosage diminished the noradrenaline-induced decrease of heart rate and increase of blood pressure.
W Sziegoleit; M Lohse; H Riedel; W Förster
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  32     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1982  
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  ger     Pagination:  218-21     Citation Subset:  IM    
Vernacular Title:
Wirkung von Allopurinol auf adrenerg induzierte Anderungen von Serumlipidkonzentrationen, Herzfrequenz und Blutdruck an normalen und myokardial vorgeschädigten Kaninchen.
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MeSH Terms
Allopurinol / pharmacology*
Blood Pressure / drug effects*
Coronary Disease / drug therapy*
Fatty Acids, Nonesterified / blood*
Heart Rate / drug effects*
Isoproterenol / pharmacology
Lipid Mobilization / drug effects
Nicotinyl Alcohol / pharmacology
Norepinephrine / pharmacology
Prostaglandins E / pharmacology
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Prostaglandins E; 100-55-0/Nicotinyl Alcohol; 315-30-0/Allopurinol; 51-41-2/Norepinephrine; 7683-59-2/Isoproterenol

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