Document Detail

Effect of allergen inhalation on the maximal response plateau of the dose-response curve to methacholine.
MedLine Citation:
PMID:  1519829     Owner:  NLM     Status:  MEDLINE    
Methacholine dose response curves (DRC) in asthmatic subjects are characterized by a leftward shift and increased maximal response. Allergen inhalation in atopic subjects shifts the DRC to the left, but the effect on the shape is unknown. This study was designed to investigate the effect of allergen inhalation on the maximal response plateau of the methacholine DRC in 16 atopic subjects; nine had mild asthma and seven had rhinitis. They were challenged with allergen and with control solutions in a single-blind design. Methacholine challenges (up to 199 mumol) were performed at baseline and 24 h after the control and allergen challenges. A plateau of the DRC was defined as a difference of less than 5% in FEV1 between the last two or more doses. The maximal response was obtained by averaging the values on the plateau and was reached by all except one subject. Allergen inhalation induced an early asthmatic response (EAR) in all subjects and an additional late asthmatic response (LAR) in 6 subjects. In subjects with an EAR alone the maximal response to methacholine 24 h after allergen challenge was not different from control (mean difference, 2.9% fall in FEV1; p greater than 0.05). In subjects with LAR, the mean value for the maximal response increased from 28.5% after control to 36.5% after allergen (mean difference, 8.0%; p less than 0.05). Of six subjects who developed LAR two lost the plateau on the DRC after allergen challenge. We conclude that allergen inhalation increases the maximal response to methacholine in those subjects who have a LAR.
W Boonsawat; C M Salome; A J Woolcock
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  146     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-10-06     Completed Date:  1992-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  565-9     Citation Subset:  AIM; IM    
Department of Medicine, University of Sydney, New South Wales, Australia.
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MeSH Terms
Administration, Inhalation
Allergens / administration & dosage*,  diagnostic use
Asthma / diagnosis,  physiopathology
Bronchial Provocation Tests / methods
Dose-Response Relationship, Drug
Dose-Response Relationship, Immunologic
Forced Expiratory Volume / drug effects
Hypersensitivity, Immediate / diagnosis,  physiopathology
Methacholine Chloride / administration & dosage*,  diagnostic use
Rhinitis / diagnosis,  physiopathology
Single-Blind Method
Skin Tests / methods
Time Factors
Reg. No./Substance:
0/Allergens; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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