Document Detail

Effect of alendronate on orthodontic tooth movement in rats.
MedLine Citation:
PMID:  19962607     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Osteoclastic activity is required for orthodontic force to move teeth through alveolar bone. Bisphosphonates are drugs that inhibit osteoclast maturation, function, and survival. The aim of this study was to assess orthodontic tooth movement in rats receiving bisphosphonate treatment. METHODS: Two groups of Sprague-Dawley rats were used. The rats in the treatment group received 7 mg per kilogram of body weight per week of alendronate sodium, and those in the control group received no drugs. A coil spring exerting a constant 50-g force was activated across the span from the central incisors to the first molar. As the first molar tipped mesially, a diastema between the first and second molars was created. Vinyl polysiloxane impressions were poured in die stone, and the diastema was measured indirectly with a charged-couple device microscope camera and Optimas software (Media Cybernetics, Newburyport, Mass). RESULTS: Statistical analysis with repeated-measures analysis of variance showed less orthodontic tooth movement in the alendronate group compared with control group (0.06 vs 0.24 mm at 2 weeks, and 0.45 vs 1.06 mm at 4 weeks; P = 0.0004 for the alendronate vs control main effect). CONCLUSIONS: This study demonstrated an inhibitory effect of alendronate administration on orthodontic tooth movement in a rat model.
Jeremy C Karras; James R Miller; James S Hodges; John P Beyer; Brent E Larson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics     Volume:  136     ISSN:  1097-6752     ISO Abbreviation:  Am J Orthod Dentofacial Orthop     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610224     Medline TA:  Am J Orthod Dentofacial Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  843-7     Citation Subset:  D; IM    
Assistant professor, Division of Orthodontics, School of Dentistry, University of Minnesota, Minneapolis, USA.
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MeSH Terms
Alendronate / pharmacology*
Alveolar Process / drug effects*
Analysis of Variance
Bone Density Conservation Agents / pharmacology*
Bone Remodeling / drug effects*
Maxilla / drug effects
Random Allocation
Rats, Sprague-Dawley
Tooth Movement*
Reg. No./Substance:
0/Bone Density Conservation Agents; 66376-36-1/Alendronate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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