| Effect of alcohols on the permeability of blood-brain barrier. | |
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MedLine Citation:
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PMID: 3983229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effect of alcohols on the permeability of blood-brain barrier was studied in anaesthetised dogs using sodium fluorescein as circulant. Entry of sodium fluorescein in the cerebrospinal fluid (CSF) was measured spectrophotofluorometrically. Methyl, ethyl, propyl and butyl alcohols were used in the study. Methyl alcohol did not increase the entry of sodium fluorescein in CSF compared to control. However, ethyl, propyl and butyl alcohols significantly increased the entry of sodium fluorescein. The increase was dependent upon the length of alkyl chain of alcohols. Longer was the aliphatic chain more marked was the effect. The increase in permeability was also dependent upon the concentration of the alcohol. Thus 90% ethyl alcohol was more effective than 30% and this effect was concentration-dependent. The increase in permeability of blood-brain barrier could be correlated to the lipid solubility of alcohols. |
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Authors:
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A Gulati; C Nath; K Shanker; R C Srimal; K N Dhawan; K P Bhargava |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacological research communications Volume: 17 ISSN: 0031-6989 ISO Abbreviation: Pharmacol Res Commun Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-05-17 Completed Date: 1985-05-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0236354 Medline TA: Pharmacol Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 85-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Propanol
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pharmacology Alcohols / pharmacology* Animals Blood-Brain Barrier / drug effects* Butanols / pharmacology Dogs Dose-Response Relationship, Drug Ethanol / pharmacology Female Fluorescein Fluoresceins / diagnostic use Male Methanol / pharmacology Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Alcohols; 0/Butanols; 0/Fluoresceins; 2321-07-5/Fluorescein; 64-17-5/Ethanol; 67-56-1/Methanol; 71-23-8/1-Propanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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