Document Detail

Effect of alcoholic beverages on postprandial glycemia and insulinemia in lean, young, healthy adults.
MedLine Citation:
PMID:  17556691     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ethanol's ability to inhibit gluconeogenesis might reduce postprandial glycemia in realistic meal settings. OBJECTIVE: The objective was to explore the effect of 3 types of alcoholic beverages consumed alone, with a meal, or 1 h before a meal on postprandial glycemia in healthy subjects. DESIGN: In study 1, isoenergetic (1000 kJ) servings of beer, white wine, and gin were compared with a 1000-kJ portion of white bread. In study 2, the same servings were compared with water as an accompaniment to a bread meal. In study 3, 20-g alcohol portions were served as a premeal drink. Fingertip capillary blood samples were taken at regular intervals over 2-3 h. RESULTS: In study 1, the mean (+/-SE) glucose scores for beer (58 +/- 11), wine (7 +/- 3), and gin (10 +/- 5) were significantly lower (P < 0.001) than those for bread (= 100). In study 2, meals consumed with beer (84 +/- 11; P = 0.03), wine (63 +/- 6; P < 0.001), and gin (80 +/- 12; P = 0.007) produced less glycemia than did the meal consumed with water (= 100). In study 3, all 3 beverages reduced the postprandial glycemic response to the subsequent meal (67 +/- 5, 75 +/- 6, and 78 +/- 4 with the beer, wine, and gin trials, respectively; P < 0.003). CONCLUSION: In realistic settings, alcoholic beverage consumption lowers postprandial glycemia by 16-37%, which represents an unrecognized mechanism by which alcohol may reduce the risk of chronic disease.
Jennie C Brand-Miller; Kaniz Fatema; Kaniz Fatima; Christopher Middlemiss; Marian Bare; Vicki Liu; Fiona Atkinson; Peter Petocz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  85     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-08     Completed Date:  2007-07-11     Revised Date:  2008-03-06    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1545-51     Citation Subset:  AIM; IM    
Human Nutrition Unit, The University of Sydney, NSW, Australia.
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MeSH Terms
Alcoholic Beverages*
Blood Glucose / drug effects*,  metabolism
Dietary Carbohydrates / pharmacology
Ethanol / pharmacology*
Gluconeogenesis / drug effects
Insulin / blood*
Middle Aged
Postprandial Period / physiology
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 11061-68-0/Insulin; 64-17-5/Ethanol
Erratum In:
Am J Clin Nutr. 2007 Sep;86(3):808
Note: Fatima, Kaniz [corrected to Fatema, Kaniz]

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