Document Detail


Effect of alcohol withdrawal on blood pressure, plasma renin activity, aldosterone, cortisol and dopamine beta-hydroxylase.
MedLine Citation:
PMID:  6373096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty-five alcoholic patients admitted for detoxification had blood pressure, withdrawal symptoms, plasma cortisol (PC) and plasma aldosterone (PA) levels, plasma renin activity (PRA), and serum dopamine beta-hydroxylase (DBH) levels measured on the first and fourth days after admission. On the morning after admission blood pressure was elevated (greater than 140/90) in 32 patients (49%) and was 160/95 mmHg or more in 21 (32%). PRA was initially elevated in 41 patients, PA levels in 14, and 13 patients had raised PC levels. By the fourth day, blood pressure and biochemical measures had fallen significantly while urine volume and sodium output, low on admission, had increased significantly. On admission urinary metanephrine levels were raised in four out of the 31 patients who had them measured. The height of both the systolic and diastolic blood pressures was significantly related to the severity of the alcohol withdrawal symptoms. Of the biochemical parameters measured, PC level correlated with systolic but not diastolic pressure, and urinary volume was inversely correlated with the height of the diastolic pressure. No relationship was found between blood pressure and PRA or PA level. The pressor effect of alcohol withdrawal could be due to sympathetic nervous system overactivity, or possibly to hypercortisolaemia . The first hypothesis seems more likely.
Authors:
L T Bannan; J F Potter; D G Beevers; J B Saunders; J R Walters; M C Ingram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  66     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-13     Completed Date:  1984-07-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  659-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alcoholism / blood,  physiopathology
Aldosterone / blood
Blood Pressure*
Dopamine beta-Hydroxylase / blood
Ethanol / adverse effects*
Female
Humans
Hydrocortisone / blood
Male
Middle Aged
Renin / blood
Substance Withdrawal Syndrome / blood,  physiopathology*
Time Factors
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 64-17-5/Ethanol; EC 1.14.17.1/Dopamine beta-Hydroxylase; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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