Document Detail

Effect of alcohol upon myoelectric activity of the gastrointestinal tract and pancreatic and biliary duct pressures.
MedLine Citation:
PMID:  4002109     Owner:  NLM     Status:  MEDLINE    
Myoelectric activity of the antrum, duodenum and sphincter of Oddi was recorded from 12 conscious opossums. The common duct and the pancreatic duct were cannulated for pressure measurements. Recordings were made in the fasted state and after gastric or duodenal administration of ethanol. Alcohol was instilled during phase I (55 experiments) or phase II (ten experiments) of the migrating myoelectric complex. Administration of alcohol caused the appearance of phase III-like activity in five to ten minutes in 91 per cent of the experiments. Pancreatic duct and common duct pressure oscillations occurred synchronously with respiratory movements and with sphincter of Oddi spike potentials. There was an increase in the number of pressure elevations related to the increase in sphincter of Oddi spike potentials after alcohol administration; however, base line pressures remained constant. It is concluded that the administration of alcohol into the stomach or duodenum causes the appearance of phase III-like activity and that there is no change in the base line pressure after the instillation of alcohol.
J C Coelho; F G Moody; N Senninger; N W Weisbrodt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  160     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-15     Completed Date:  1985-07-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  528-33     Citation Subset:  AIM; IM    
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MeSH Terms
Bile Ducts / drug effects*,  physiology
Duodenum / drug effects*,  physiology
Ethanol / pharmacology*
Pancreas / drug effects*,  physiology
Stomach / drug effects*,  physiology
Reg. No./Substance:

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