Document Detail

Effect of alcohol-induced septal ablation on left atrial volume and ejection fraction assessed by real time three-dimensional transthoracic echocardiography in patients with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  18754938     Owner:  NLM     Status:  MEDLINE    
Alcohol-induced septal ablation (AISA) is an accepted treatment for hypertrophic cardiomyopathy (HCM) patients with left ventricular (LV) outflow obstruction who are unresponsive to medical therapy. As left atrial (LA) enlargement has been correlated with increased morbidity and mortality in HCM, we assessed LA volumes and ejection fraction (EF) prior to and after AISA using real time three-dimensional (3D) transthoracic echocardiography (TTE) in 12 patients (9 women; mean age 52 +/- 15 years; 11 Caucasian). All patients underwent successful AISA with no complications and their resting left ventricular outflow gradients decreased from 40.5 +/- 22.2 to 9.1 +/- 17.6 mmHg (P < 0.001) while their gradients with provocation decreased from 126.2 +/- 31.7 to 21.8 +/- 28.0 mmHg (P < 0.001). All patients showed improvements in their New York Heart Association (NYHA) functional class. Both the LA end-systolic (45.2 +/- 12.9 to 37.2 +/- 13.7 ml, P < 0.0001) and end-diastolic (79.6 +/- 18.9 to 77.1 +/- 18.6 ml, P = 0.001) volumes decreased after AISA. The LA EF increased from 43.1 +/- 9.0 to 52.5 +/- 8.8% (P = 0.001). The increase in LA EF correlated with the decrease in the resting left ventricular outflow gradient (R =-0.647, P = 0.03). In conclusion, 3D echocardiography can be utilized to follow LA function after AISA for HCM. AISA results in clinical improvement in patients with HCM and in improvement of LA EF that is correlated with the decrease in the left ventricular outflow gradient.
Fadi G Hage; Gultekin Karakus; William D Luke; Thouantosaporn Suwanjutah; Manjula V Burri; Navin C Nanda; Raed A Aqel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  25     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-29     Completed Date:  2009-01-06     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  784-9     Citation Subset:  IM    
Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0007, USA.
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MeSH Terms
Cardiomyopathy, Hypertrophic / mortality,  therapy*,  ultrasonography*
Cohort Studies
Echocardiography, Three-Dimensional / methods*
Echocardiography, Transesophageal*
Ethanol / therapeutic use*
Follow-Up Studies
Heart Catheterization
Heart Function Tests
Heart Septum / drug effects*
Linear Models
Middle Aged
Observer Variation
Risk Assessment
Severity of Illness Index
Stroke Volume
Survival Analysis
Treatment Outcome
Ventricular Remodeling
Reg. No./Substance:
Erratum In:
Echocardiography. 2008 Oct;25(9):ii
Note: Burri, Manjula V [added]

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