| Effect of alcohol-induced septal ablation on left atrial volume and ejection fraction assessed by real time three-dimensional transthoracic echocardiography in patients with hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 18754938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alcohol-induced septal ablation (AISA) is an accepted treatment for hypertrophic cardiomyopathy (HCM) patients with left ventricular (LV) outflow obstruction who are unresponsive to medical therapy. As left atrial (LA) enlargement has been correlated with increased morbidity and mortality in HCM, we assessed LA volumes and ejection fraction (EF) prior to and after AISA using real time three-dimensional (3D) transthoracic echocardiography (TTE) in 12 patients (9 women; mean age 52 +/- 15 years; 11 Caucasian). All patients underwent successful AISA with no complications and their resting left ventricular outflow gradients decreased from 40.5 +/- 22.2 to 9.1 +/- 17.6 mmHg (P < 0.001) while their gradients with provocation decreased from 126.2 +/- 31.7 to 21.8 +/- 28.0 mmHg (P < 0.001). All patients showed improvements in their New York Heart Association (NYHA) functional class. Both the LA end-systolic (45.2 +/- 12.9 to 37.2 +/- 13.7 ml, P < 0.0001) and end-diastolic (79.6 +/- 18.9 to 77.1 +/- 18.6 ml, P = 0.001) volumes decreased after AISA. The LA EF increased from 43.1 +/- 9.0 to 52.5 +/- 8.8% (P = 0.001). The increase in LA EF correlated with the decrease in the resting left ventricular outflow gradient (R =-0.647, P = 0.03). In conclusion, 3D echocardiography can be utilized to follow LA function after AISA for HCM. AISA results in clinical improvement in patients with HCM and in improvement of LA EF that is correlated with the decrease in the left ventricular outflow gradient. |
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Authors:
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Fadi G Hage; Gultekin Karakus; William D Luke; Thouantosaporn Suwanjutah; Manjula V Burri; Navin C Nanda; Raed A Aqel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 25 ISSN: 1540-8175 ISO Abbreviation: Echocardiography Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-29 Completed Date: 2009-01-06 Revised Date: 2009-02-02 |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 784-9 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0007, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiomyopathy, Hypertrophic / mortality, therapy*, ultrasonography* Cohort Studies Echocardiography, Three-Dimensional / methods* Echocardiography, Transesophageal* Ethanol / therapeutic use* Female Follow-Up Studies Heart Catheterization Heart Function Tests Heart Septum / drug effects* Humans Linear Models Male Middle Aged Observer Variation Probability Risk Assessment Severity of Illness Index Stroke Volume Survival Analysis Treatment Outcome Ventricular Remodeling |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
| Comments/Corrections | |
Erratum In:
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Echocardiography. 2008 Oct;25(9):ii Note: Burri, Manjula V [added] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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