Document Detail

Effect of airways constriction on exhaled nitric oxide.
MedLine Citation:
PMID:  18218918     Owner:  NLM     Status:  MEDLINE    
While airway constriction has been shown to affect exhaled nitric oxide (NO), the mechanisms and location of constricted airways most likely to affect exhaled NO remain obscure. We studied the effects of histamine-induced airway constriction and ventilation heterogeneity on exhaled NO at 50 ml/s (Fe(NO,50)) and combined this with model simulations of Fe(NO,50) changes due to constriction of airways at various depths of the lung model. In 20 normal subjects, histamine induced a 26 +/- 15(SD)% Fe(NO,50) decrease, a 9 +/- 6% forced expiratory volume in 1 s (FEV(1)) decrease, a 19 +/- 9% mean forced midexpiratory flow between 25% and 75% forced vital capacity (FEF(25-75)) decrease, and a 94 +/- 119% increase in conductive ventilation heterogeneity. There was a significant correlation of Fe(NO,50) decrease with FEF(25-75) decrease (P = 0.006) but not with FEV(1) decrease or with increased ventilation heterogeneity. Simulations confirmed the negligible effect of ventilation heterogeneity on Fe(NO,50) and showed that the histamine-induced Fe(NO,50) decrease was due to constriction, with associated reduction in NO flux, of airways located proximal to generation 15. The model also indicated that the most marked effect of airways constriction on Fe(NO,50) is situated in generations 10-15 and that airway constriction beyond generation 15 markedly increases Fe(NO,50) due to interference with the NO backdiffusion effect. These mechanical factors should be considered when interpreting exhaled NO in lung disease.
Sylvia Verbanck; Yannick Kerckx; Daniel Schuermans; Walter Vincken; Manuel Paiva; Alain Van Muylem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-24
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  104     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-03     Completed Date:  2008-06-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  925-30     Citation Subset:  IM    
Respiratory Division, Univ. Hospital UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
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MeSH Terms
Bronchoconstriction / physiology*
Computer Simulation
Diving / physiology
Forced Expiratory Volume / physiology
Histamine / diagnostic use
Lung / physiology
Lung Diseases / physiopathology
Models, Anatomic
Models, Statistical
Nitric Oxide / metabolism*
Respiratory Mechanics / physiology
Vital Capacity / physiology
Reg. No./Substance:
10102-43-9/Nitric Oxide; 51-45-6/Histamine
Comment In:
J Appl Physiol (1985). 2008 Apr;104(4):909-11   [PMID:  18258805 ]

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