Document Detail

Effect of aging on the renin angiotensin system in patients with renovascular hypertension.
MedLine Citation:
PMID:  1619967     Owner:  NLM     Status:  MEDLINE    
The effect of aging on the renin angiotensin system (RAS) was studied in 30 patients with renovascular hypertension and 33 patients with essential hypertension. Plasma renin decreased with age in patients with renovascular hypertension and essential hypertension. However, in patients with renovascular hypertension, the change was not statistically significant. Plasma aldosterone concentration showed a tendency to decrease with age in both groups. Stimulated plasma renin activity and the net increase in plasma renin activity after captopril administration in patients with essential hypertension showed a significant decrease with age. In patients with renovascular hypertension, exaggerated response of renin secretion was observed in younger patients, but middle-aged and elderly patients did not demonstrate this hyper-responsiveness. The degree of decrease in blood pressure by administration of an angiotensin (Ang) II analog ([Sar1,Ile8] Ang II) was the same in both younger and elderly patients with either disease. These results suggest that the effect of aging on the RAS occurs not only in patients with essential hypertension, but also in patients with renovascular hypertension. Furthermore, although the Ang II analog infusion test and captopril stimulation test are considered to be useful screening tests for renovascular hypertension, we consider that the combination of Ang II analog test and captopril test may be favorable to screen renovascular hypertension, since the captopril stimulation test had a lower sensitivity in younger (under 35 years old) patients.
R Morishita; J Higaki; H Mikami; N Matsukawa; T Ogihara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  14     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:    1992 Jan-Feb
Date Detail:
Created Date:  1992-08-06     Completed Date:  1992-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Department of Geriatric Medicine, Osaka University Medical School, Japan.
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MeSH Terms
Aging / physiology*
Aldosterone / blood
Angiotensin II / administration & dosage,  pharmacology
Blood Pressure / drug effects
Captopril / administration & dosage,  pharmacology
Hypertension, Renovascular / physiopathology*
Middle Aged
Renin-Angiotensin System / drug effects,  physiology*
Reg. No./Substance:
11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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