| Effect of age and restricted feeding on polypeptide chain assembly kinetics in liver protein synthesis in vivo. | |
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MedLine Citation:
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PMID: 1715006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polypeptide assembly rates during in vivo hepatic protein synthesis were studied as a function of age and restricted feeding in male rats. With ageing the time to assemble the average peptide in the liver of fully-fed rats significantly increased. In young rats maintained on a restricted feeding regime known to retard ageing, the time to assemble the average polypeptide was increased 2.5 times. With ageing the rate of peptide elongation increased so that at 2 years of age the underfed animals assembled peptides at a significantly faster rate than their age-matched controls. The rate of elongation of peptides during hepatic protein synthesis was shown to be directly dependent upon circulating T3 levels rather than the dietary status of the animal. On refeeding young diet restricted rats, polypeptide assembly kinetics did not immediately return to control values although the rate of protein synthesis was significantly increased. Total liver RNA content increased significantly in refed animals allowing for a greater rate of chain initiation to offset the slow rate of chain elongation. A period of 28 days of ad libitum feeding was required before assembly kinetics returned to control values and is probably indicative of a persistent impaired monodeiodination of T4 to T3. |
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Authors:
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B J Merry; A M Holehan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 58 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-09-26 Completed Date: 1991-09-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 139-50 Citation Subset: IM |
Affiliation:
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Institute of Human Ageing, University of Liverpool, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism* Animals Diet* Kinetics Liver / drug effects, metabolism* Male Peptide Chain Elongation, Translational / drug effects, physiology Protein Biosynthesis* RNA / metabolism Rats Rats, Inbred Strains Triiodothyronine / pharmacology |
| Chemical | |
Reg. No./Substance:
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63231-63-0/RNA; 6893-02-3/Triiodothyronine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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