Document Detail

Effect of age on cerebrospinal fluid levels of metabolites of biopterin and biogenic amines.
MedLine Citation:
PMID:  10626519     Owner:  NLM     Status:  MEDLINE    
We identified an age effect on biopterin and biogenic amine metabolites in the cerebrospinal fluid from 56 neurologically normal patients, aged 1 mo to 80 y. The levels of total and reduced forms of biopterin, homovanillic acid, and 5-hydroxyindoleacetic acid were found to peak during the first year of life. The levels of these metabolites then gradually decreased, plateauing at the age of 20 y. We found significant correlations between biopterin, homovanillic acid, and 5-hydroxy-indoleacetic acid.
H Komori; T Matsuishi; S Yamada; N Ueda; Y Yamashita; H Kato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  88     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-20     Completed Date:  2000-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1344-7     Citation Subset:  IM    
Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume City, Fukuoka, Japan.
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MeSH Terms
Age Factors
Aged, 80 and over
Biogenic Amines / cerebrospinal fluid*
Biopterin / cerebrospinal fluid*
Child, Preschool
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Infant, Newborn
Middle Aged
Reg. No./Substance:
0/Biogenic Amines; 22150-76-1/Biopterin; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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