Document Detail

Effect of age and alpha-linolenic acid deficiency on delta 6 desaturase activity and liver lipids in rats.
MedLine Citation:
PMID:  8102769     Owner:  NLM     Status:  MEDLINE    
The combined effects of age and of diet deficient in n-3 fatty acids on delta 6 desaturation of linoleic acid and on lipid fatty acid composition were studied in the liver of the rat at 2, 6, 12, 18 and 24 mon of age. The profiles of delta 6 desaturase activity and fatty acid composition were studied in the deficient rats refed, at these different ages, either with 18:3n-3 (mixture of peanut and rapeseed oils) or with 20:5n-3 + 22:6n-3 (fish oil) diets for 2, 4, 8 or 12 wk. Results showed that the liver delta 6 desaturation activity in the control rats remained high at 2 and 6 mon, decreased by 30% from 6 to 12 mon, and then remained stable from 12 to 24 mon. In the deficient rats, this activity remained high during the entire period studied. Thus, the profile of liver delta 6 desaturase activity after puberty was not related to age only; it also depended on the polyunsaturated fatty acid (PUFA) n-6 and n-3 balance in the diet. In the controls, in parallel with the delta 6 desaturase activity, PUFA metabolism could be divided into three periods: a "young" period, and "old age" period, separated by a period of transition between 6 and 12 mon. Recovery from PUFA n-3 deficiency occurred at all ages but in a different manner depending on whether the rats were "young" or "old". Recovery was faster if long-chain n-3 PUFA rather than alpha-linolenic acid were supplied in the diet.
T K Dinh; J M Bourre; G Durand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  28     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-17     Completed Date:  1993-09-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  517-23     Citation Subset:  IM    
Laboratoire de Nutrition et de Sécurité Alimentaire, INRA 78352 Jouy-en-Josas, France.
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MeSH Terms
Aging / physiology*
Dietary Fats / analysis
Fatty Acid Desaturases / metabolism*
Fatty Acids / analysis
Linolenic Acids / deficiency*
Linoleoyl-CoA Desaturase
Lipids / chemistry
Liver / chemistry*,  enzymology*
Rats, Wistar
alpha-Linolenic Acid
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Linolenic Acids; 0/Lipids; 463-40-1/alpha-Linolenic Acid; EC 1.14.19.-/Fatty Acid Desaturases; EC Desaturase

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