Document Detail

Effect of aflatoxin on the humoral and cell-mediated immune systems of the chicken.
MedLine Citation:
PMID:  24399     Owner:  NLM     Status:  MEDLINE    
Chickens fed 2.5 microgram of aflatoxin/g of diet from 2 to 4 weeks of age or from hatching to 4 weeks were deficient in cell-mediated immunity, as measured at 4 weeks of age by the graft-versus-host reaction. Delayed-type hypersensitive skin reactions to tuberculin were also reduced in chickens given dietary aflatoxin from hatching to 7 weeks of age. Humoral immunity, as measured by the ability of 4-week-old chicks to produce natural agglutinins to rabbit red blood cells, was not significantly altered by dietary aflatoxin. A significant decrease in concentrations of serum immunoglobulins (Ig) IgG and IgA, but no IgM, however, did occur in chicks given dietary aflatoxin from hatching to 4 weeks or between 2 and 4 weeks of age. Aflatoxin consumption from 0 to 2 weeks of age produced no marked effect on either cell-mediated or humoral immunity in 4-week-old chicks.
J J Giambrone; D L Ewert; R D Wyatt; C S Eidson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  39     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-04-26     Completed Date:  1978-04-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-8     Citation Subset:  IM    
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MeSH Terms
Aflatoxins / toxicity*
Antibody Formation*
Chickens / immunology*
Graft vs Host Reaction
Immunity, Cellular*
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Poultry Diseases / chemically induced,  immunology
Skin Tests
Reg. No./Substance:
0/Aflatoxins; 0/Immunoglobulin A; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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