Document Detail


Effect of aerosolized dipalmitoyl lecithin on oxygen-toxic rat lungs.
MedLine Citation:
PMID:  1173344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary surfactant is reduced in oxygen toxicity but whether this represents a decrease in production or inactivation of surface-active material already present is not known. We divided 200 g male Wister-Lewis rats into different experimental groups. The animals were exposed continuously to 0, 48, 56 or 72 h of close to 100% oxygen at atmospheric pressure. Administration of aerosolized dipalmitoyl lecithin (DPL) in phosphate buffer had no effect on lung deflation compliances or lung stability indices of any group. Exposure to DPL by spontaneous respiration and/or controlled ventilation made no difference. Lung dry/wet weight ratios fell in animals exposed to aerosols of DPL + buffer + O2, buffer + O2, or water + O2, to aerosols of DPL + buffer + O2, buffer + O2, or water + O2, as compared to animals with similar lengths of oxygen exposure not exposed to an aerosol. If the initial pulmonary pathophysiological response to 100% oxygen at 1 atm pressure is capillary logical response to 100% oxygen at 1 atm pressure is capillary endothelial damage with leakage of intravascular fluids into the alveoli, then exogenously administered DPL would not be of benefit in pulmonary oxygen toxicity. Our study suggests that aerosolized DPL administered to normal animals and animals exposed to oxygen for 48-72 h had no effect on lung compliance or stability.
Authors:
J B Brodsky
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  46     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-07-20     Completed Date:  1975-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  668-70     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Aerosols
Animals
Lung / drug effects
Lung Compliance / drug effects*
Male
Organ Size
Oxygen / toxicity*
Phosphatidylcholines / administration & dosage,  pharmacology*
Pulmonary Surfactants
Rats
Temperature
Time Factors
Chemical
Reg. No./Substance:
0/Aerosols; 0/Phosphatidylcholines; 0/Pulmonary Surfactants; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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