Document Detail


Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women.
MedLine Citation:
PMID:  16979409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adipocytokines secreted by adipose tissue are suggested to play a role in the development of obesity-related complications. Regular aerobic exercise has been shown to reduce the risk of metabolic complications in obese subjects. The aim of this study was to investigate the effect of aerobic training on gene expression in subcutaneous abdominal adipose tissue (SCAAT) and on plasma levels of several adipocytokines in obese women. Twenty-five obese sedentary premenopausal women (body mass index, 32.18 +/- 3.17 kg/m(2)) underwent a 12-week aerobic exercise program, with a frequency of 5 d/wk and intensity corresponding to 50% of individual maximal oxygen consumption (V(.-)(O(2)max)) consisting of 2 sessions per week of supervised aerobic exercise and 3 sessions per week of home-based exercise on a bicycle ergometer. Before and after the aerobic training, (V(.-)(O(2)max)) and body composition were measured and plasma and SCAAT biopsy samples (in a subgroup of 8 subjects) were obtained for determination of plasma and messenger RNA levels of adipocytokines (leptin, adiponectin, interleukin 6, tumor necrosis factor alpha). The aerobic training resulted in an increase of subjects' V o(2)max by 12.8% (24.6 +/- 3.9 vs 27.7 +/- 4.8 mL x min(-1) x kg(-1), P < .05). Body weight and fat mass were reduced by 5.9% (88.5 +/- 8.2 vs 83.3 +/- 7.7 kg, P < .001) and 6.4% (38.8 +/- 4.2% vs 36.3 +/- 4.6%, P < .001), respectively, and the revised QUantitative Insulin sensitivity ChecK Index (QUICKI) increased (0.43 +/- 0.06 vs 0.48 +/- 0.06, P < .05) during the aerobic training. No aerobic training-induced changes in messenger RNA levels of the investigated genes in SCAAT were observed. A decrease of plasma leptin (24.3 +/- 8.7 vs 18.1 +/- 8.3 ng/mL, P < .05) was detected, whereas plasma levels of other cytokines remained unchanged. In moderately obese females, 3 months' aerobic training did not promote changes in the adipose tissue gene expression or plasma levels of the adipocytokines (except for leptin) involved in a regulation of lipid and carbohydrate metabolism.
Authors:
Jan Polak; Eva Klimcakova; Cedric Moro; Nathalie Viguerie; Michel Berlan; Jindriska Hejnova; Blanka Richterova; Ivan Kraus; Dominique Langin; Vladimir Stich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  55     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-18     Completed Date:  2006-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1375-81     Citation Subset:  IM    
Affiliation:
Franco-Czech Laboratory for Clinical Research on Obesity, Third Medical Faculty and INSERM Unite 586, Charles University, Prague, Czech Republic. jan.polak@totes.hyperlink.cz
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MeSH Terms
Descriptor/Qualifier:
Abdominal Fat / metabolism*
Adiponectin / biosynthesis*,  genetics
Adipose Tissue / metabolism*
Adult
Blood Glucose / metabolism
Body Composition
Diet
Exercise / physiology*
Female
Humans
Interleukin-6 / biosynthesis*,  genetics
Kinetics
Obesity / genetics,  metabolism*
Oxygen Consumption / physiology
Physical Fitness
Prospective Studies
RNA, Messenger / biosynthesis,  genetics
Triglycerides / blood
Tumor Necrosis Factor-alpha / biosynthesis*,  genetics
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Blood Glucose; 0/Interleukin-6; 0/RNA, Messenger; 0/Triglycerides; 0/Tumor Necrosis Factor-alpha

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