Document Detail


Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus.
MedLine Citation:
PMID:  11045758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of aerobic exercise intervention on the renal functional and ultrastructural changes associated with diabetes mellitus were studied in the obese Zucker rat, a rat model of type 2 diabetes. The obese Zucker rats began training at 18 wk of age (n=8) and were compared to obese sedentary controls (n=12) and lean sedentary nondiseased littermates (n=10). Body weight, kidney weight, serum creatinine, urine creatinine, creatinine clearance, urine IgG, urine IgG/creatinine ratio, urine total protein, urine albumin, urine albumin/creatinine ratio, glycated hemoglobin, serum fructosamine, fasting serum glucose, serum insulin, serum total cholesterol, serum triglycerides, blood pressure, and morphometric analyses of cortical glomeruli by light microscopy and electron microscopy were performed to evaluate renal function, structure, and metabolic control. The exercise training consisted of treadmill running, 5 da/wk for 1 hr/da. Exercise intervention lowered the body weight (p <0.05), reduced the percentage of glycated hemoglobin (p <0.05), and diminished the urine albumin concentration (p <0.05), compared to the obese sedentary controls. Exercise intervention did not significantly affect morphometric indices of renal ultrastructure. This study shows that aerobic exercise intervention significantly improved metabolic control and reduced albuminuria in a rat model of type 2 diabetes.
Authors:
J M Chiasera; K M Ward-Cook; S A McCune; G M Wardlaw
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  30     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-19     Completed Date:  2001-02-15     Revised Date:  2004-11-18    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  346-53     Citation Subset:  IM    
Affiliation:
Medical Technology Division, Ohio State University, Columbus 43210, USA. chiasera.1@osu.edu
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MeSH Terms
Descriptor/Qualifier:
Albuminuria / metabolism,  pathology,  therapy
Animals
Blood Glucose
Blood Pressure
Cholesterol / blood
Creatinine / urine
Diabetes Mellitus / metabolism*,  pathology,  therapy
Diabetes Mellitus, Type 2 / metabolism*,  pathology,  therapy
Diabetic Nephropathies / metabolism*,  pathology,  therapy
Disease Models, Animal
Fructosamine / blood
Hemoglobin A, Glycosylated / analysis
Insulin / blood
Kidney / metabolism,  ultrastructure
Kidney Glomerulus / metabolism,  pathology
Male
Obesity*
Organ Size
Physical Conditioning, Animal / physiology*
Rats
Rats, Zucker
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Triglycerides; 11061-68-0/Insulin; 4429-04-3/Fructosamine; 57-88-5/Cholesterol; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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