Document Detail

Effect of adrenalectomy and high-fat diet on the fatty Zucker rat.
MedLine Citation:
PMID:  1733248     Owner:  NLM     Status:  MEDLINE    
Lean and obese Zucker fatty rats were adrenalectomized or sham operated at 10 wk of age. At 15 wk one-half of each group was placed on a high-fat diet. At 32 wk of age the experiment was ended. Several conclusions can be drawn about the effects of adrenalectomy, high-fat diets, and their interaction in the Zucker fatty rat. First, adrenalectomy slowed the weight gain in both obese fatty rats and in the lean animals, although the effect was greater in the fatty rats. Second, weight gain was accelerated in intact lean and fatty rats eating a high-fat diet. Third, adrenalectomy attenuated the weight gain associated with a high-fat diet and reduced the body content of fat and protein in the lean animals and fatty rats fed the low-fat diet. Fifth, adrenalectomy significantly affected the retroperitoneal and subcutaneous fat depots but not the epididymal fat depot. Sixth, adrenalectomy decreased fat cell number in retroperitoneal and subcutaneous fat depots, but this was much less evident in the epididymal fat depot. Seventh, lipoprotein lipase activity expressed per milligram protein increased after adrenalectomy in the fatty rat but was reduced on the same basis in lean animals regardless of diet. Finally, the increase in retroperitoneal lipoprotein lipase activity expressed per fat cell observed in lean animals fed the high-fat diet was not observed in the fatty rat. These studies show that a high-fat diet and adrenalectomy interact in the development of obesity in both lean and fatty Zucker rats.
G A Bray; J S Stern; T W Castonguay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  262     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-21     Completed Date:  1992-02-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E32-9     Citation Subset:  IM    
Department of Medicine, University of Southern California, Los Angeles 90033.
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MeSH Terms
Adipose Tissue / metabolism,  pathology
Analysis of Variance
Body Composition
Body Weight
Dietary Fats / pharmacology*
Insulin / blood
Lipoprotein Lipase / metabolism
Obesity / blood,  metabolism*,  pathology
Rats, Zucker / anatomy & histology,  metabolism*
Reg. No./Substance:
0/Dietary Fats; 11061-68-0/Insulin; EC Lipase

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