Document Detail


Effect of the admixture of tetracycline and nadifloxacin ointments on their stability and their antibacterial activity
MedLine Citation:
PMID:  18670189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impetigo contagiosa staphylogenes is commonly treated by administering a combination of nadifloxacin and tetracycline ointments. However, it is not clear whether nadifloxacin and tetracycline are stable after mixing. The purpose of this study was to evaluate the stability of these agents in combination. We also evaluated changes in antibacterial activity after mixing. Mixing the two ointments caused tetracycline to change from yellow to brown in the admixture. Furthermore, the tetracycline content in the ointment decreased in a time-dependent manner, to about 40% at 288 h after mixing. In addition, the nadifloxacin content in the ointment did not change 288 h after mixing. In an alkaline environment (pH 9.0 and 11.0), the tetracycline content decreased and the color of tetracycline changed to brown. These results suggest that sodium hydroxide, which is an additive in nadifloxacin ointment, influences the content of tetracycline. We evaluated the chemical sensitivity of Staphylococcus aureus using disk tests. Nadifloxacin and tetracycline ointment showed the largest radius of inhibition circle, followed by the admixture 0 h after mixing and the admixture 72 h after mixing. These results suggest that the antibacterial activity is inhibited by the admixture. We propose that pharmacists should avoid mixing nadifloxacin with tetracycline ointment in the treatment of impetigo contagiosa staphylogenes and should take care to avoid interactions caused by additives in the ointments.
Authors:
Tsunetaka Kawamoto; Yoshitaka Tayama; Akihiro Sawa; Takami Monde; Susumu Sashima; Mari Yoshioka; Katushi Miyake; Shushi Morita; Kenji Kihira
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Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan     Volume:  128     ISSN:  0031-6903     ISO Abbreviation:  Yakugaku Zasshi     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-09-26     Revised Date:  2009-12-17    
Medline Journal Info:
Nlm Unique ID:  0413613     Medline TA:  Yakugaku Zasshi     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  1221-6     Citation Subset:  IM    
Affiliation:
Owl Pharmacy, My Life Co., Ltd, Kure City, Japan.
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MeSH Terms
Descriptor/Qualifier:
Drug Combinations
Drug Interactions
Drug Resistance, Bacterial
Drug Stability
Fluoroquinolones* / pharmacology
Hydrogen-Ion Concentration
Ointments
Quinolizines* / pharmacology
Staphylococcus aureus / drug effects
Tetracycline* / pharmacology
Time Factors
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Fluoroquinolones; 0/Ointments; 0/Quinolizines; 124858-35-1/nadifloxacin; 60-54-8/Tetracycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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