| Effect of adjuvants in the isotypes and bactericidal activity of antibodies against the transferrin-binding proteins of Neisseria meningitidis. | |
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MedLine Citation:
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PMID: 9713939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-eight Neisseria meningitidis strains of different serogroups, serotypes, and TbpB isotypes were used to test the effect of five adjuvant formulations on the immune response to the meningococcal transferrin-binding proteins (Tbps) in mice. Levels of anti-Tbps antibodies were relatively low when purified TbpA-TbpB complexes were used for immunization, those obtained with the RAS adjuvant being the highest, and the isotype distribution reveals a prevalence of the non-bactericidal IgG1. Specific anti-Tbps antibody levels were five to 125 times higher immunizing with whole outer membrane vesicles, with bactericidal isotypes prevailing, which suggests that presentation of these antigens in their natural conformation is crucial to elicit a good response. Nevertheless, bactericidal activity did not correlate with these characteristics, confirming that it must be also influenced by other factors, and direct evaluation of the killing ability is necessary to draw conclusions about the efficacy of antigens or adjuvants in vaccine design. |
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Authors:
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J A Gómez; E Hernández; M T Criado; C M Ferreirós |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Vaccine Volume: 16 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1998-10-22 Completed Date: 1998-10-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1633-9 Citation Subset: IM |
Affiliation:
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Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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pharmacology* Animals Antibodies, Bacterial / blood*, immunology* Bacterial Proteins / immunology* Blood Bactericidal Activity* Carrier Proteins / immunology* Cross Reactions Immunoglobulin Isotypes / blood* Iron-Binding Proteins Mice Mice, Inbred BALB C Neisseria meningitidis / immunology* Transferrin-Binding Proteins |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Carrier Proteins; 0/Immunoglobulin Isotypes; 0/Iron-Binding Proteins; 0/Transferrin-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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