Document Detail

Effect of adipic dihydrazide modification on the performance of collagen/hyaluronic acid scaffold.
MedLine Citation:
PMID:  19810117     Owner:  NLM     Status:  MEDLINE    
Collagen and hydrazide-functionalized hyaluronic acid derivatives were hybridized by gelating and genipin crosslinking to form composite hydrogel. The study contributed to the understanding of the effects of adipic dihydrazide modification on the physicochemical and biological properties of the collagen/hyaluronic acid scaffold. The investigation included morphology observation, mechanical measurement, swelling evaluation, and collagenase degradation. The results revealed that the stability of composites was increased through adipic dihydrazide modification and genipin crosslinking. The improved biocompatibility and retention of hyaluronic acid made the composite material more favorable to chondrocytes growing, suggesting the prepared scaffold might be high potential for chondrogenesis.
Ling Zhang; Yumei Xiao; Bo Jiang; Hongsong Fan; Xingdong Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  92     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-16     Citation Subset:  IM    
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
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MeSH Terms
Absorbable Implants
Adipic Acids / chemistry*
Cell Adhesion
Cell Proliferation
Chondrocytes / physiology
Collagen Type I / chemistry*
Cross-Linking Reagents
Enzymes / chemistry
Hyaluronic Acid / chemistry*
Iridoids / chemistry
Materials Testing
Microscopy, Electron, Scanning
Spectrophotometry, Infrared
Spectroscopy, Fourier Transform Infrared
Stress, Mechanical
Tensile Strength
Tissue Scaffolds / chemistry*
Water / chemistry
Reg. No./Substance:
0/Adipic Acids; 0/Collagen Type I; 0/Cross-Linking Reagents; 0/Enzymes; 0/Iridoids; 1071-93-8/adipic dihydrazide; 6902-77-8/genipin; 7732-18-5/Water; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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