Document Detail

Effect of adenosine triphosphate on canine renal circulation.
MedLine Citation:
PMID:  2452315     Owner:  NLM     Status:  MEDLINE    
The effect of adenosine triphosphate (ATP) on systemic and renal hemodynamics was studied in seven dogs anesthetized with pentobarbital and enflurane. Adenosine triphosphate was given via the vena cava, the left atrium, and the abdominal aorta close to the left renal artery. Bolus injection of ATP in the vena cava showed a dose-dependent decrease of mean arterial pressure and renal blood flow, while cardiac output showed only a slight change. Continuous infusion of ATP in the vena cava or the left atrium showed stable hypotension, decrease of renal blood flow, with slight change of cardiac output. Despite the decrease of total peripheral resistance (TRP), renal vascular resistance (RVR) increased significantly in all cases. However, the continuous infusion of ATP into the abdominal aorta close to the left renal artery caused variable responses of systemic arterial pressure and a significant decrease of the RVR. These results suggest that ATP has a renal vasodilator effect only when given directly into the renal artery, and that a renal vasoconstriction occurs responding to the systemic effect of ATP when ATP is given intravenously or into the left atrium.
S Hashimoto; T Natsuyama; T Mitsufuji; Y Tanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  11     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-05-27     Completed Date:  1988-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-8     Citation Subset:  IM    
Department of Anesthesiology, Kyoto Prefectural University of Medicine, Japan.
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MeSH Terms
Adenosine Triphosphate / administration & dosage,  pharmacology*
Aorta, Abdominal
Cardiac Output / drug effects
Heart Atria
Hemodynamics / drug effects*
Renal Circulation / drug effects*
Vascular Resistance / drug effects
Venae Cavae
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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