Document Detail

Effect of adenosine on isolated and superfused cat carotid body activity.
MedLine Citation:
PMID:  2366949     Owner:  NLM     Status:  MEDLINE    
Adenosine is known to increase carotid chemoreceptor discharge in vivo. Since adenosine has powerful vascular effects it is possible that this chemoexcitation is indirectly caused by changes in carotid body blood flow. To evaluate this possibility the effect of adenosine (0.02-2.0 mumol) was assessed on the chemoreceptor activity of the cat carotid bodies in vitro. All three doses of adenosine produced an increase in chemoreceptor discharge which reached its maximum within 10-20 s and subsequently returned to preinjection controls within 1 min. The chemoreceptor excitation caused by adenosine was dose-dependent. These results suggest that adenosine induces chemoexcitation without changes in blood pressure and blood flow.
M Runold; N S Cherniack; N R Prabhakar
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  113     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM    
Department of Medicine, University Hospitals, Case Western Reserve University, Cleveland, OH.
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MeSH Terms
Action Potentials / drug effects
Adenosine / pharmacology*
Carotid Body / drug effects,  physiology*
Chemoreceptor Cells / drug effects,  physiology*
Grant Support
Reg. No./Substance:

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