Document Detail


Effect of adenosine on isolated and superfused cat carotid body activity.
MedLine Citation:
PMID:  2366949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenosine is known to increase carotid chemoreceptor discharge in vivo. Since adenosine has powerful vascular effects it is possible that this chemoexcitation is indirectly caused by changes in carotid body blood flow. To evaluate this possibility the effect of adenosine (0.02-2.0 mumol) was assessed on the chemoreceptor activity of the cat carotid bodies in vitro. All three doses of adenosine produced an increase in chemoreceptor discharge which reached its maximum within 10-20 s and subsequently returned to preinjection controls within 1 min. The chemoreceptor excitation caused by adenosine was dose-dependent. These results suggest that adenosine induces chemoexcitation without changes in blood pressure and blood flow.
Authors:
M Runold; N S Cherniack; N R Prabhakar
Related Documents :
8922309 - Comparison of intravenous adenosine to intracoronary papaverine for calculation of pres...
25354779 - Current dietary salt intake of japanese individuals assessed during health check-up.
7814609 - 31p-nuclear magnetic resonance studies of chronic myocardial ischemia in the yucatan mi...
7967679 - Myocardial buffering capacity and high-energy phosphate utilization during hypothermic ...
15550519 - Reduced oxygen supply explains the negative force-frequency relation and the positive i...
9278239 - Analysis of inositol phosphates in heart tissue using anion-exchange high-performance l...
7057229 - Oral glycerol for the treatment of traumatic intracranial hypertension.
2530869 - Pharmacodynamics of amlodipine: hemodynamic effects and antianginal efficacy after atri...
9931079 - A test of the "epinephrine hypothesis" in humans.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  113     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, University Hospitals, Case Western Reserve University, Cleveland, OH.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Adenosine / pharmacology*
Animals
Carotid Body / drug effects,  physiology*
Cats
Chemoreceptor Cells / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
HL-38986/HL/NHLBI NIH HHS; HL-39921/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differential effect of neurointermediate lobectomy on central oxytocin and vasopressin.
Next Document:  Magnesium ions prevent phencyclidine-induced cerebrovasospasms and rupture of cerebral microvessels:...