Document Detail


Effect of adenosine and deoxyadenosine on the incorporation and breakdown of thymidine in Escherichia coli K-12.
MedLine Citation:
PMID:  4914568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deoxyadenosine (AdR) and adenosine (AR) enhance the incorporation of thymidine (TdR) into bacterial deoxyribonucleic acid (DNA) by the inhibition of TdR phosphorolysis in vivo. Neither of the purine nucleosides has an effect on the reaction catalyzed by TdR phosphorylase in vitro. AdR induces TdR phosphorylase and both purine nucleosides induce purine nucleoside phosphorylase. AR can stimulate uptake of more TdR into bacterial DNA than AdR.
Authors:
E Yagil; A Rosner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  103     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1970 Aug 
Date Detail:
Created Date:  1970-09-10     Completed Date:  1970-09-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  417-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
DNA, Bacterial / biosynthesis
Enzyme Induction
Escherichia coli / enzymology,  metabolism*
Glucosyltransferases / metabolism
Nucleosides / pharmacology*
Nucleotidyltransferases / metabolism
Thymidine / metabolism*
Tritium
Chemical
Reg. No./Substance:
0/DNA, Bacterial; 0/Nucleosides; 10028-17-8/Tritium; 50-89-5/Thymidine; EC 2.4.1.-/Glucosyltransferases; EC 2.7.7.-/Nucleotidyltransferases
Comments/Corrections

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