| Effect of adenoidectomy on respiratory function: a randomised prospective study. | |
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MedLine Citation:
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PMID: 19131420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Risk of childhood asthma is increased in children with recurrent otitis media. This may be associated with recurrent respiratory tract infections in these children, but the role of adenoidectomy, a frequent operation during childhood, is unknown. Therefore, the role of adenoidectomy in the development of atopy and respiratory function changes characteristic of asthma was evaluated. DESIGN: Randomised controlled study. SETTING: Tertiary care centre. Patients: 166 children aged 12-48 months who had recurrent or persistent otitis media and who were followed-up for 3 years after randomisation. INTERVENTION: Randomisation to undergo insertion of tympanostomy tubes with or without adenoidectomy. MAIN OUTCOME MEASURES: The primary outcome measure was exercise-induced bronchoconstriction as evaluated by impulse oscillometry. The secondary outcome measures were bronchial inflammation as evaluated by exhaled nitric oxide and atopy as evaluated by skin prick tests. During the 3-year follow-up period otitis media episodes were documented in patient diaries. RESULTS: Adenoidectomy did not significantly influence baseline lung function, exercise-induced bronchoconstriction, exhaled nitric oxide concentration, the development of positive skin prick tests, or doctor-diagnosed asthma. Adenoidectomy did not significantly prevent otitis media. Recurrent otitis media (>or=4 episodes) during the first follow-up year was associated with an abnormal exercise-induced bronchoconstriction (OR 6.62, 95% CI 1.27 to 34) and an elevated exhaled nitric oxide concentration (OR 3.26, 95% CI 0.98 to 10.8) regardless of adenoidectomy. CONCLUSIONS: Adenoidectomy did not promote asthma or allergy. Recurrent respiratory tract infections during early childhood are associated with the risk of bronchial hyper-reactivity. |
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Authors:
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P S Mattila; S Hammarén-Malmi; A S Pelkonen; L P Malmberg; M J Mäkelä; H Saxen; J Tarkkanen |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-01-08 |
Journal Detail:
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Title: Archives of disease in childhood Volume: 94 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-22 Completed Date: 2009-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: England |
Other Details:
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Languages: eng Pagination: 366-70 Citation Subset: AIM; IM |
Affiliation:
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Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland. petri.mattila@hus.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoidectomy
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adverse effects* Adolescent Age Factors Asthma / etiology* Bronchoconstriction Child Female Humans Male Middle Ear Ventilation / methods Oscillometry / methods Otitis Media / prevention & control*, surgery Prospective Studies Recurrence Respiratory Tract Infections / etiology*, surgery Skin Tests |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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