Document Detail


Effect of addition of a probiotic microorganism to broiler diets contaminated with deoxynivalenol on performance and histological alterations of intestinal villi of broiler chickens.
MedLine Citation:
PMID:  16776464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An experiment was conducted to study the effects of deoxynivalenol (DON) on the performance of broilers, organ weights, and intestinal histology and to evaluate the efficacy of a probiotic feed additive (PB, Eubacterium sp.) with the ability to deepoxidize DON. Two hundred seventy-seven 1-d-old broiler chicks were randomly assigned to 1 of the 3 dietary treatments for 6 wk. The dietary treatments were 1) control; 2) artificially contaminated diets with 10 mg of DON/kg of diet; 3) DON-contaminated diets plus probiotic feed additive (DON-PB). The BW and the efficiency of feed utilization were not adversely affected (P > 0.05) by the inclusion of DON in the diets. A slight improvement in feed intake and BW gain over the course of the experiment was observed in broilers fed DON-PB with no change in feed efficiency. The absolute or relative organ weights were not altered (P > 0.05) in broilers fed the diet containing DON compared with controls and the DON-PB group. The absolute liver weights were numerically increased (P < 0.1) for broilers receiving the diet containing DON-PB. There were no significant differences in the absolute and relative weights of the gizzard, duodenum, pancreas, heart, and spleen. However, the absolute and relative weights of the jejunum and cecum were increased for DON-PB-fed broilers compared with the controls and DON group. No pathological lesions were found in the gut of birds fed DON-contaminated diets during the feeding trial, but mild intestinal changes were observed. The DON altered small intestinal morphology, especially in the duodenum and jejunum, where villi were shorter and thinner (P < 0.05). The addition of the eubacteria to the DON-contaminated feed of the broilers effectively alleviated the histological alterations caused by DON and led to comparable villus length as in the control group. In conclusion, diets with DON contamination below levels that induce a negative impact on health and performance could affect small intestinal morphology in broilers. The histological alterations caused by DON were reduced by supplementing the DON-containing diets with PB. This indicates that in case of DON contamination of feedstuffs, the addition of PB would be a proper way to counteract the possible effects caused by this mycotoxin.
Authors:
W A Awad; J Böhm; E Razzazi-Fazeli; K Ghareeb; J Zentek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  85     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-16     Completed Date:  2006-07-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  974-9     Citation Subset:  IM    
Affiliation:
Institute of Nutrition, University of Veterinary Medicine, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cecum / pathology
Chickens
Diet*
Eating
Female
Food Additives
Food Contamination / analysis*
Intestinal Diseases / chemically induced,  pathology,  veterinary*
Intestines / pathology
Jejunum / pathology
Liver / pathology
Male
Organ Size
Poultry Diseases / chemically induced,  pathology*,  prevention & control
Probiotics / administration & dosage*
Trichothecenes / analysis,  toxicity*
Weight Gain
Chemical
Reg. No./Substance:
0/Food Additives; 0/Trichothecenes; 51481-10-8/deoxynivalenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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