| Effect of addition of botulinum toxin-A to standardized therapy for dynamic manual skills measured with kinematic aiming tasks in children with spastic hemiplegia. | |
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MedLine Citation:
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PMID: 20461335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To measure the effect of intensive therapy and the lasting effect of a standardized functional training programme with vs. without the addition of chemodernervation of the muscles of the forearm and hand. PATIENTS AND METHODS: Twenty children with spastic hemiplegia, aged 4-16 years, were matched for baseline characteristics and randomized to standardized task-oriented therapy for 6 months with or without botulinum toxin injections. Dynamic kinematic outcome measures were: speed, accuracy, end-point spread and performance. Measurements of active and passive range of motion, stretch-restricted angle of the elbow and wrist, Ashworth scores and Melbourne Assessment of Unilateral Upper Limb Function were made. All measures were performed at baseline, 2 weeks after injection of botulinum toxin and after 6 months (at the end of therapy), and 3 months after end of the therapy. RESULTS: Clinical measures showed improvement in both groups. However, no significant differences emerged between groups on functional measures. Directly after the botulinum toxin injection all kinematic outcome measures showed a decrease, but baseline values were re-established during the therapy period. After botulinum toxin injections a temporarily significant greater increase in speed and performance was found. These results illustrate the need for further quantitative research into the effects of botulinum toxin. |
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Authors:
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Eugene A A Rameckers; Jacques Duysens; Lucianne A W M Speth; Hans J S Vles; Bouwien C M Smits-Engelsman |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine Volume: 42 ISSN: 1651-2081 ISO Abbreviation: J Rehabil Med Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088169 Medline TA: J Rehabil Med Country: Sweden |
Other Details:
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Languages: eng Pagination: 332-8 Citation Subset: IM |
Affiliation:
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Rehabilitation Foundation Limburg (SRL), Valkenburg, The Netherlands. eaa.rameckers@hetnet.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Adolescent Botulinum Toxin Type A / therapeutic use* Cerebral Palsy / drug therapy*, physiopathology, rehabilitation Child Child, Preschool Follow-Up Studies Hemiplegia / drug therapy*, physiopathology, rehabilitation Humans Motor Skills Neuromuscular Agents / therapeutic use* Outcome Assessment (Health Care) Range of Motion, Articular / physiology Task Performance and Analysis Treatment Outcome Upper Extremity / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxin Type A; 0/Neuromuscular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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