Document Detail

Effect of adding clofazimine to combined clarithromycin-ethambutol therapy for Mycobacterium avium complex septicemia in AIDS patients.
MedLine Citation:
PMID:  10192709     Owner:  NLM     Status:  MEDLINE    
This study compared the efficacies of clarithromycin-ethambutol and clarithromycin-ethambutol-clofazimine for the treatment of Mycobacterium avium complex (MAC) in AIDS patients. Thirty-four patients were randomized into two groups to receive clarithromycin 2 g/day and ethambutol 20 mg/kg/day, with or without clofazimine 200 mg/day. The evaluation was based primarily on blood cultures becoming negative after 2 months of therapy, but survival at 12 months and clinical evolution were also assessed. Inclusions were prematurely stopped because of a communication reporting increased mortality associated with clofazimine. At 2 months, the blood cultures of 55% of the clarithromycin-ethambutol group patients versus 81% of the clarithromycin-ethambutol-clofazimine group were negative; this difference is not significant (P=0.42). Only one relapse was observed during the study. No clarithromycin-resistant strain was isolated. No apparent difference in either survival or clinical evolution was observed in this small number of patients (median survival, 144 days in the clarithromycin-ethambutol group and 236 days in the clarithromycin-ethambutol-clofazimine group, P=0.44). The clarithromycin-ethambutol combination appears to be an effective and well-tolerated first-line therapy against MAC infections in AIDS patients.
S Fournier; A M Burguière; A Flahault; V Vincent; M P Treilhou; M Eliaszewicz
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  18     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-04     Completed Date:  1999-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  16-22     Citation Subset:  IM; X    
Department of Infectious Diseases, Hôpital Saint-Louis, Paris, France.
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MeSH Terms
AIDS-Related Opportunistic Infections / drug therapy*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Bacteremia / drug therapy*
Clarithromycin / therapeutic use*
Clofazimine / therapeutic use*
Drug Therapy, Combination / therapeutic use
Ethambutol / therapeutic use*
Middle Aged
Mycobacterium avium Complex
Mycobacterium avium-intracellulare Infection / drug therapy*
Survival Analysis
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 2030-63-9/Clofazimine; 74-55-5/Ethambutol; 81103-11-9/Clarithromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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