Document Detail

Effect of adafenoxate on different rat brain structures monoamine oxidase activity in vitro.
MedLine Citation:
PMID:  2576744     Owner:  NLM     Status:  MEDLINE    
1. The effect of the nootropic drug adafenoxate on monoamine oxidase (MAO) activity in rat brain cortex, striatum, hypothalamus and hippocampus has been studied using the following substrates: tyramine (total MAO), serotonin (MAO A) and beta-phenylethylamine (MAO B). 2. In a series of increased concentrations (from 5 x 10(-4) up to 1 x 10(-5) M) adafenoxate inhibits total MAO, MAO A and MAO B in the brain structures studied. 3. The adafenoxate IC50 values obtained illustrate its inhibitory properties and its lack of selectivity toward MAO in the brain structures isolated. 4. The results of our research prove the participation of MAO in the mechanisms through which adafenoxate affects the brain monoaminergic systems and realises its central effects.
S Stancheva; P Kunova
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology     Volume:  94     ISSN:  0742-8413     ISO Abbreviation:  Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-05-30     Completed Date:  1990-05-30     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8310013     Medline TA:  Comp Biochem Physiol C     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Department of Experimental Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
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MeSH Terms
Brain / drug effects*,  enzymology
Glycolates / pharmacology*
Meclofenoxate / analogs & derivatives,  pharmacology*
Monoamine Oxidase Inhibitors*
Rats, Inbred Strains
Reg. No./Substance:
0/Glycolates; 0/Monoamine Oxidase Inhibitors; 3685-84-5/Meclofenoxate; 82168-26-1/adafenoxate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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