Document Detail


Effect of adafenoxate on different rat brain structures monoamine oxidase activity in vitro.
MedLine Citation:
PMID:  2576744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The effect of the nootropic drug adafenoxate on monoamine oxidase (MAO) activity in rat brain cortex, striatum, hypothalamus and hippocampus has been studied using the following substrates: tyramine (total MAO), serotonin (MAO A) and beta-phenylethylamine (MAO B). 2. In a series of increased concentrations (from 5 x 10(-4) up to 1 x 10(-5) M) adafenoxate inhibits total MAO, MAO A and MAO B in the brain structures studied. 3. The adafenoxate IC50 values obtained illustrate its inhibitory properties and its lack of selectivity toward MAO in the brain structures isolated. 4. The results of our research prove the participation of MAO in the mechanisms through which adafenoxate affects the brain monoaminergic systems and realises its central effects.
Authors:
S Stancheva; P Kunova
Related Documents :
3123604 - Selegiline and the prophylaxis of parkinson's disease.
24073314 - The effect of cochinchina momordica seed extract on gastric acid secretion and morpholo...
1184414 - Histochemical study of monoamine oxidase latency in the liver of the rat.
3363224 - Inhibition of the rat hepatic mixed-function oxidases by in vivo administration of clot...
15987844 - All-trans retinoic acid antagonizes the action of calciferol and its active metabolite,...
1385084 - Development of epileptic activity induced by iron injection into rat cerebral cortex: e...
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology     Volume:  94     ISSN:  0742-8413     ISO Abbreviation:  Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-05-30     Completed Date:  1990-05-30     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8310013     Medline TA:  Comp Biochem Physiol C     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Affiliation:
Department of Experimental Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects*,  enzymology
Glycolates / pharmacology*
Male
Meclofenoxate / analogs & derivatives,  pharmacology*
Monoamine Oxidase Inhibitors*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Glycolates; 0/Monoamine Oxidase Inhibitors; 3685-84-5/Meclofenoxate; 82168-26-1/adafenoxate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of emulsified perfluorochemicals on liver cytochromes P-450 in rats.
Next Document:  Alterations in rat mineral metabolism induced by acute ammonium acetate infusion.