| Effect of acute variations in dietary fat and carbohydrate intake on retinyl ester content of intestinally derived lipoproteins. | |
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MedLine Citation:
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PMID: 1727825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitamin A was administered to eight patients with noninsulin-dependent diabetes mellitus in conjunction with the two different test meals containing (as percentage of total calories) either 15% protein, 60% carbohydrate (CHO), and 25% fat or 15% protein, 40% CHO, and 45% fat. The vitamin A and test meals were given at noon (4 h after a standard breakfast), and blood was obtained hourly from noon to midnight for measurement of plasma glucose, insulin, triglyceride (TG), and cholesterol concentrations; concentrations of TG and cholesterol in Sverdberg floatation (Sf) unit above 400 and Sf 20-400 lipoproteins; retinyl ester concentration in plasma; and both Sf more than 400 and Sf 20-400 lipoproteins. The postprandial TG response in plasma, Sf more than 400 lipoproteins, and Sf 20-400 lipoproteins from noon to midnight was only slightly higher than values seen after consumption of the 60% CHO diet, which contained much less fat (25% vs. 45%) and the retinyl ester concentration was actually higher in both lipoprotein fractions after the diet containing the smallest amount of fat (60% CHO). Furthermore, the cholesterol concentration in the plasma and two lipoprotein fractions was identical after the two diets, despite the great difference in fat content. These data indicate that the acute ingestion of high CHO (60%), low fat (25%) diets by patients with noninsulin-dependent diabetes mellitus led to little or no decrease in postprandial plasma or lipoprotein TG or cholesterol concentrations and an actual increase in concentration of potentially atherogenic small chylomicron and/or chylomicron remnants. |
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Authors:
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Y D Chen; R Skowronski; A M Coulston; J Pietarinen; C B Hollenbeck; G M Reaven |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 74 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-01-30 Completed Date: 1992-01-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 28-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Stanford University School of Medicine, California. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Cholesterol / blood Diabetes Mellitus, Type 2 / metabolism Dietary Carbohydrates / pharmacology* Dietary Fats / pharmacology* Eating Humans Intestines / metabolism* Lipoproteins / metabolism* Male Middle Aged Time Factors Triglycerides / blood Vitamin A / analogs & derivatives*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL-08506/HL/NHLBI NIH HHS; RR-00070/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Fats; 0/Lipoproteins; 0/Triglycerides; 11103-57-4/Vitamin A; 57-88-5/Cholesterol; 79-81-2/retinol palmitate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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