| Effect of acute treatment of mice with L-histidine on the brain levels of amino acids. | |
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MedLine Citation:
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PMID: 2724677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The brain histidine level in mice dose-dependently increased 1 and 2 hr after an i.p. injection of 0.5-1.5 g/kg of L-histidine. The treatment with 1.0 and 1.5 g/kg but not 0.5 g/kg of L-histidine significantly decreased the brain levels of tyrosine, phenylalanine and some other amino acids 1 hr later. A complete recovery or a rebound rise of amino acid levels was observed 2 hr after treatment. These results indicate that there is a change in the transport of amino acids into the brain after treatment with large doses of L-histidine. |
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Authors:
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R Oishi; K Furuno; Y Gomita; Y Araki; K Saeki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese journal of pharmacology Volume: 49 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-06-29 Completed Date: 1989-06-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 143-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Okayama University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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analysis* Animals Brain Chemistry / drug effects* Dose-Response Relationship, Drug Histidine / pharmacology* Male Mice Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 71-00-1/Histidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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