| Effect of acute and prolonged mineralocorticoid receptor blockade on spontaneous and stimulated hypothalamic-pituitary-adrenal axis in humans. | |
| | |
MedLine Citation:
|
PMID: 20219855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONTEXT: Mineralocorticoid receptors (MRs) in the hippocampus display an important role in the control of the hypothalamic-pituitary-adrenal (HPA) axis, mediating the proactive feedback of glucocorticoids, which maintains the basal HPA activity. The systemic administration of MR antagonists enhances spontaneous and CRH-stimulated ACTH, cortisol, and DHEA secretion, while the effects of chronic treatment with MR antagonists are scanty. Our study was performed in order to clarify this point. DESIGN: ACTH, cortisol, and DHEA levels were studied during the infusion of placebo, canrenoate, a MR antagonist (CAN, 200 mg i.v. bolus at 1600 h followed by 200 mg infused over 4 h), and human CRH (hCRH; 2.0 microg/kg i.v. bolus at 1800 h) before and during the last week of 28-day treatment with CAN (200 mg/day p.o.) in eight young women. RESULTS: Pre-treatment sessions: CAN and hCRH administration increased ACTH, cortisol, and DHEA levels versus placebo (P<0.05). Post-treatment sessions: during placebo infusion, cortisol and DHEA were significantly amplified versus pre-treatment session (P<0.05), while ACTH levels were not modified; CAN infusion, differently from pre-treatment session, was not able to significantly increase ACTH, cortisol, and DHEA levels; ACTH, cortisol, and DHEA responses to hCRH were amplified with respect to pre-treatment session, although statistical significance was obtained for cortisol and DHEA only. CONCLUSIONS: MR blockade by acute CAN administration significantly enhances the HPA activity in the afternoon, during the quiescent phase of the circadian rhythm. At the same period, prolonged treatment with CAN amplifies both spontaneous and CRH-stimulated activities of the HPA axis, while it blunts the HPA responsiveness to a further MR-mediated stimulation. |
| | |
Authors:
|
Rita Berardelli; Ioannis Karamouzis; Elisa Marinazzo; Elisa Prats; Andreea Picu; Roberta Giordano; Ezio Ghigo; Emanuela Arvat |
Related Documents
:
|
2836825 - Pulsatile acth secretion: variation with time of day and relationship to cortisol. 6277605 - Apparent dissociation of adrenocorticotropin and corticosteroid responses to 15 ml/kg h... 175085 - Corticotropic action of an intra-nasally applied synthetic acth derivative. 1846875 - High testosterone levels of ovarian origin affect adrenal steroidogenesis? 9157945 - Segregation analysis of plasma apolipoprotein b levels in familial combined hyperlipide... 16564715 - Thiourea-induced thyroid hormone depletion impairs testicular recrudescence in the air-... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-10 |
Journal Detail:
|
Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 162 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-21 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 1067-74 Citation Subset: IM |
Affiliation:
|
Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Ospedale S. Giovanni Battista-Molinette, C.so Dogliotti 14, Turin, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Glands
/
drug effects,
physiology Adrenocorticotropic Hormone / secretion Adult Analysis of Variance Canrenoate Potassium / pharmacology Corticotropin-Releasing Hormone / pharmacology Dehydroepiandrosterone / secretion Female Humans Hydrocortisone / secretion Hypothalamo-Hypophyseal System / drug effects*, physiology Hypothalamus / drug effects, physiology Pituitary Gland / drug effects, physiology Pituitary-Adrenal System / drug effects*, physiology Receptors, Mineralocorticoid / antagonists & inhibitors*, physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Mineralocorticoid; 2181-04-6/Canrenoate Potassium; 50-23-7/Hydrocortisone; 53-43-0/Dehydroepiandrosterone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorex...
Next Document: Ultrasound-guided fine-needle aspiration of thyroid nodules: stratification of malignancy risk using...