| Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin e levels. | |
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MedLine Citation:
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PMID: 19195504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glutathione peroxidase 1 (GPX-1) has an important role in antioxidant defense and has been suggested to have a protective role against the pathogenesis of atherosclerosis. In the present study, erythrocytic GPX-1 activity from 42 patients with acute myocardial infarction and 285 healthy control subjects of Taiwanese origin were determined. Our data showed that mean GPX-1 activity decreased in patients with acute myocardial infarction (40.7 +/- 9.2 vs 47.3 +/- 16.6 U/g hemoglobin; p <0.001). There was a significant inverse correlation between GPX-1 activity and acute myocardial infarction incidence (p = 0.032). In addition, plasma vitamin E inversely correlated with acute myocardial infarction incidence (p = 0.017). The incidence of acute myocardial infarction increased only in patients with low plasma vitamin E and low erythrocytic GPX-1 activity, but not in those with high vitamin E and low GPX-1 activity, low vitamin E and high GPX-1 activity, or high vitamin E and high GPX-1 activity. In conclusion, acute myocardial infarction incidence significantly increased in patients with a concomitant decrease in plasma vitamin E and erythrocytic GPX-1 activity, suggesting that both GPX-1 and vitamin E may be valuable markers for monitoring cardiovascular events, particularly when used in combination. |
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Authors:
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Mei-ling Cheng; Chin-ming Chen; Hung-yao Ho; Jui-ming Li; Daniel Tsun-yee Chiu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-25 |
Journal Detail:
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Title: The American journal of cardiology Volume: 103 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-06 Completed Date: 2009-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 471-5 Citation Subset: AIM; IM |
Affiliation:
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Graduate Institute of Medical Biotechnology, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Case-Control Studies Erythrocytes / enzymology* Female Glutathione Peroxidase / metabolism* Humans Incidence Male Middle Aged Myocardial Infarction / blood*, enzymology*, epidemiology Taiwan Vitamin E / blood* |
| Chemical | |
Reg. No./Substance:
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1406-18-4/Vitamin E; EC 1.11.1.-/glutathione peroxidase GPX1; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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