Document Detail

Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin e levels.
MedLine Citation:
PMID:  19195504     Owner:  NLM     Status:  MEDLINE    
Glutathione peroxidase 1 (GPX-1) has an important role in antioxidant defense and has been suggested to have a protective role against the pathogenesis of atherosclerosis. In the present study, erythrocytic GPX-1 activity from 42 patients with acute myocardial infarction and 285 healthy control subjects of Taiwanese origin were determined. Our data showed that mean GPX-1 activity decreased in patients with acute myocardial infarction (40.7 +/- 9.2 vs 47.3 +/- 16.6 U/g hemoglobin; p <0.001). There was a significant inverse correlation between GPX-1 activity and acute myocardial infarction incidence (p = 0.032). In addition, plasma vitamin E inversely correlated with acute myocardial infarction incidence (p = 0.017). The incidence of acute myocardial infarction increased only in patients with low plasma vitamin E and low erythrocytic GPX-1 activity, but not in those with high vitamin E and low GPX-1 activity, low vitamin E and high GPX-1 activity, or high vitamin E and high GPX-1 activity. In conclusion, acute myocardial infarction incidence significantly increased in patients with a concomitant decrease in plasma vitamin E and erythrocytic GPX-1 activity, suggesting that both GPX-1 and vitamin E may be valuable markers for monitoring cardiovascular events, particularly when used in combination.
Mei-ling Cheng; Chin-ming Chen; Hung-yao Ho; Jui-ming Li; Daniel Tsun-yee Chiu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-25
Journal Detail:
Title:  The American journal of cardiology     Volume:  103     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-06     Completed Date:  2009-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  471-5     Citation Subset:  AIM; IM    
Graduate Institute of Medical Biotechnology, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taipei, Taiwan.
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MeSH Terms
Case-Control Studies
Erythrocytes / enzymology*
Glutathione Peroxidase / metabolism*
Middle Aged
Myocardial Infarction / blood*,  enzymology*,  epidemiology
Vitamin E / blood*
Reg. No./Substance:
1406-18-4/Vitamin E; EC 1.11.1.-/glutathione peroxidase GPX1; EC Peroxidase

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