Document Detail


Effect of acute, multiple-dose ethanol on maternal and fetal blood gases and acid-base balance in the near-term pregnant ewe.
MedLine Citation:
PMID:  2505916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of ethanol on maternal and fetal blood gases and acid-base balance was determined in six conscious instrumented near-term pregnant ewes for maternal intravenous infusion of 3 g ethanol/kg total body weight administered as six doses of 0.5 g ethanol/kg total body weight over 8 h. Maternal and fetal blood ethanol concentrations, determined in two animals, were maximal at 8 h (3.74 and 3.82 mg/mL, respectively) and were virtually identical during the 24-h study. Maternal and fetal blood gases and acid-base balance were not significantly altered during and after ethanol administration compared with preinfusion values. The data demonstrate that, during near-term ovine pregnancy, the equivalent of a binge-type drinking episode does not produce fetal hypoxia or acidosis. Furthermore, these data do not support the postulated involvement of ethanol-induced fetal hypoxia in the mechanism of ethanol teratogenesis.
Authors:
G N Smith; J F Brien; L Carmichael; D W Clarke; J Patrick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  67     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-10-20     Completed Date:  1989-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  686-8     Citation Subset:  IM    
Affiliation:
Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Canada.
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium / drug effects*
Animals
Blood Gas Analysis*
Carbon Dioxide / metabolism
Ethanol / pharmacology*
Female
Fetus / metabolism*
Gestational Age
Hydrogen-Ion Concentration
Oxygen Consumption / drug effects
Pregnancy
Pregnancy, Animal / drug effects*
Sheep
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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