| Effect of acute ketoacidosis on the myocardium in diabetes. | |
| | |
MedLine Citation:
|
PMID: 8615375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Abnormalities of left ventricular function are often present in patients with diabetes who are in a stable metabolic state. To determine whether acute metabolic abnormalities may contribute to pathogenesis, patients with diabetes and ketoacidosis (Group 1) or hyperglycemia without ketosis (Group 2) were studied. They were assessed noninvasively for evidence of acute injury or dysfunction of the myocardium. Left ventricular function was assessed on admission and after clinical recovery. Myocardial enzyme release was examined during the acute phase. In Group 1, plasma glucose averaged 32 mM/L and carbon dioxide content 12.4 mEq/L. On echocardiography, the initial circumferential shortening velocity of 1.85 + 0.07 circumferences per second was significantly higher than the final circumferential shortening velocity of 1.31 + 01 (P < 0.005). The systolic time interval ratio, pre-ejection period/left ventricular ejection time, was significantly lower on the initial day compared with the second study. These data are consistent with enhanced ventricular performance. In group 2, plasma glucose averaged 29 mM/L, and carbon dioxide content was normal. The initial circumferential shortening velocity of 1. 1 circumferences per second and pre-ejection period/left ventricular ejection time ratio of 0.38 were normal and remained unchanged. There was no significant alteration of heart rate or arterial pressure in either group. In both groups, total serum lactate dehydrogenase and creatinine phosphokinase levels, as well as their cardiac isoenzymes, were within normal limits. Therefore, the initial increase of myocardial performance and subsequent restoration to normal, as well as the lack of cardiac enzyme increase in plasma, support the view that shortterm ketoacidosis does not contribute to the abnormalities of ventricular function in diabetes. |
| | |
Authors:
|
A K George; A Shih; T J Regan |
Related Documents
:
|
8078825 - Transmitral doppler assessment of left ventricular diastolic function during coronary a... 9207615 - Evaluation of diastolic filling of left ventricle in health and disease: doppler echoca... 16442355 - Comparison of usefulness of left ventricular diastolic versus systolic function as a pr... 21996395 - Quantitative relationship between the extent and morphology of coronary atherosclerotic... 16055175 - Differences between left and right ventricular anatomy determine the types of reentrant... 1572025 - Radiofrequency catheter ablation of ventricular tachycardia in patients without structu... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of the medical sciences Volume: 311 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1996 Feb |
Date Detail:
|
Created Date: 1996-06-05 Completed Date: 1996-06-05 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 61-4 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adult Diabetes Mellitus / metabolism* Diabetic Ketoacidosis / physiopathology* Electrocardiography Female Heart / physiopathology* Humans Male Myocardial Contraction |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Limits of metabolic tolerance to copper and biological basis for present recommendations and regulat...
Next Document: Suppression of cellular proliferation using p53 DNA recognition site-related oligonucleotides.