Document Detail

Effect of acute ischaemia on active and passive large deformation mechanics of canine carotid arteries.
MedLine Citation:
PMID:  546047     Owner:  NLM     Status:  MEDLINE    
Large deformation mechanical properties of dog carotid arteries excised following 1 hour of ischaemia and 1 hour of reperfusion were compared to those of contralaterial normal arteries in vitro. Vascular smooth muscle was invariably activated by 0.5 microgram/ml noradrenaline. Relative reduction in the diameter of postischaemia arteries following noradrenaline administration was twice as large (max.: 13.2 +/- 2.0%) as that of normal controls (max.: 5.7 +/- 1.5%) in the pressure range of 0--220 mmHg. If the smooth muscle was totally relaxed there were no differences between the geometrical (wall-thickness, radius) and mechanical properties (stress, incremental elastic modulus, incremental distensibility, strain-energy density) of the arteries in the two series. It is concluded that the increased reactivity of postischaemic arteries is not caused by changes in geometric or mechanical properties of their passive wall elements.
E Monos; A G Kovách
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta physiologica Academiae Scientiarum Hungaricae     Volume:  54     ISSN:  0001-6756     ISO Abbreviation:  Acta Physiol Acad Sci Hung     Publication Date:  1979  
Date Detail:
Created Date:  1980-07-12     Completed Date:  1980-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0371156     Medline TA:  Acta Physiol Acad Sci Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  23-31     Citation Subset:  IM    
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MeSH Terms
Carotid Arteries / drug effects,  physiology,  physiopathology*
Ischemia / physiopathology*
Muscle, Smooth, Vascular / drug effects
Norepinephrine / pharmacology
Vascular Resistance
Reg. No./Substance:

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